The use of rabies immune globulin by emergency physicians

The Journal of Emergency Medicine
David A Jerrard

Abstract

We sought to determine the incidence of practice patterns by emergency physicians that are non-compliant with present day World Health Organization recommendations regarding the administration of rabies immune globulin (RIG) in the prophylaxis of rabies. Of the 110 patients receiving RIG for rabies-prone wounds, 46 patients (41.8%; 95% CI 32-51.6%) were felt to have received the immunoglobulin in improper amounts at the bite site. In 43 of these 46 patients (92.8%; 95% CI 81.1-98.3%), there was a physician-written order on the chart directing the RIG be given in the older 50:50 method (one-half at the bite site, one-half elsewhere). Large numbers of patients still receive RIG inappropriately according to World Health Organization guidelines and more recently issued recommendations from the Advisory Committee on Immunization Practices. Treatment failures have been felt to occur secondary to inadequate RIG levels in wounds prophylaxed using the outdated recommendation. Emergency physicians need to be well versed and up to date with newer guidelines when prophylaxing patients for possible rabies exposure.

References

May 1, 1996·The Journal of Emergency Medicine·R A Harrigan, F H Kauffman
Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H WildeV Sitprija
Apr 1, 1997·Emerging Infectious Diseases·M Auslander, C Kaelin
Aug 5, 1998·Journal of Public Health Management and Practice : JPHMP·J W KrebsJ E Childs
Aug 17, 2000·JAMA : the Journal of the American Medical Association·G J MoranJ E Childs
Aug 31, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sharon L MessengerCharles E Rupprecht

❮ Previous
Next ❯

Citations

Aug 10, 2006·Medicine, Health Care, and Philosophy·Stephen Tyreman
Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·Dawei GaoKun Li
Feb 11, 2021·Human Vaccines & Immunotherapeutics·Nicholas Hobart-PorterJames Linakis
Jul 16, 2021·PLoS Neglected Tropical Diseases·Gavin T HowingtonJoshua T Swan
Jul 6, 2021·Pharmacotherapy·P Brandon BookstaverGavin T Howington
Dec 2, 2021·PLoS Neglected Tropical Diseases·Weerapong ThanapongtharmAnuwat Wiratsudakul

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.