The Use of Radiation Therapy in Localized High-Grade Soft Tissue Sarcoma and Potential Impact on Survival

Annals of Surgical Oncology
Chun-Han HouWilliam C Eward

Abstract

It is a consensus that radiation therapy (RT) should be applied for all large, deep, high-grade soft tissue sarcomas (STS). Therefore, we investigated the National Cancer Database (NCDB) to study how these guidelines are being followed, to determine what factors may be associated with the decision not to use RT, and to see whether there was an association of RT use and survival. We retrospectively analyzed localized high-grade STS patients in the NCDB from 1998 through 2006. They were further stratified into two groups: no radiation (NRT) group and radiation (RT) group. Then, long-term survival between the two groups was evaluated using the Kaplan-Meier (KM) method with comparisons based on the log-rank test. Multiple variables were analyzed between the two groups. Propensity matching was performed secondarily to minimize the influence of confounding variables. A total of 3982 of 10,290 patients (37.8 %) did not receive RT and 6,308 patients (62.2 %) did receive RT. Patients in the NRT group were more likely to have a below-median education level (median 58.2 % vs. 60.7 %; p = 0.015) and a below-median income level (65.1 % vs. 68.6 %; p < 0.001). In addition, these patients lived farther from their treatment centers (20.2 vs. 1...Continue Reading

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Citations

Aug 21, 2016·The Surgical Clinics of North America·Brooke K Leachman, Thomas J Galloway
Nov 30, 2018·Clinical Orthopaedics and Related Research·Alexander L LazaridesWilliam C Eward
Aug 1, 2020·The Bone & Joint Journal·Tomohiro FujiwaraAdesegun Abudu
Dec 12, 2020·The Journal of Small Animal Practice·B Wustefeld-JanssensH Wilson-Robles
Feb 12, 2020·The Journal of Surgical Research·Linda M PakChandrajit P Raut

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