The use of rodent models to investigate host-bacteria interactions related to periodontal diseases

Journal of Clinical Periodontology
Dana T GravesGeorge Hajishengallis

Abstract

Even though animal models have limitations, they are often superior to in vitro or clinical studies in addressing mechanistic questions and serve as an essential link between hypotheses and human patients. Periodontal disease can be viewed as a process that involves four major stages: bacterial colonization, invasion, induction of a destructive host response in connective tissue and a repair process that reduces the extent of tissue breakdown. Animal studies should be evaluated in terms of their capacity to test specific hypotheses rather than their fidelity to all aspects of periodontal disease initiation and progression. Thus, each of the models described below can be adapted to test discrete components of these four major steps, but not all of them. This review describes five different animal models that are appropriate for examining components of host-bacteria interactions that can lead to breakdown of hard and soft connective tissue or conditions that limit its repair as follows: the mouse calvarial model, murine oral gavage models with or without adoptive transfer of human lymphocytes, rat ligature model and rat Aggregatibacter actinomycetemcomitans feeding model.

References

Dec 1, 1979·Bulletin of Environmental Contamination and Toxicology·M H Wong
Sep 1, 1992·Journal of Periodontology·U ZappaD Case
May 1, 1992·Journal of Periodontal Research·S OffenbacherP Goldhaber
Feb 15, 1991·Science·D E MosierS A Spector
Mar 1, 1989·Oral Microbiology and Immunology·G Dahlén, J Slots
Sep 1, 1989·Endocrinology·B F BoyceG R Mundy
Apr 1, 1988·Journal of Periodontology·M E Cohen, S A Ralls
May 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·J B ClarkW N Shaw
Jan 1, 1984·Journal of Clinical Periodontology·S S SocranskyJ Lindhe
Aug 1, 1981·Journal of Clinical Periodontology·R Kenworthy, M Baverel
Aug 1, 1982·Journal of Periodontology·T E Van DykeM J Levine
Oct 1, 1982·The Journal of Infectious Diseases·W ZimmerliU E Nydegger
Jan 1, 1980·Laboratory Animals·W Simpson, D J Simmons
Jun 1, 1994·Research in Immunology·N HozumiJ S Sandhu
Feb 1, 1995·The British Journal of Oral & Maxillofacial Surgery·L J Peterson
Oct 1, 1994·Journal of Clinical Periodontology·A GyörfiL Rosivall
Oct 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M KoideK Hara
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·I A DarbyD G MacLellan
Dec 8, 1998·Journal of Periodontal Research·E LallaA M Schmidt

❮ Previous
Next ❯

Citations

Mar 27, 2012·Nature Immunology·Mehmet A EskanGeorge Hajishengallis
Mar 23, 2010·Molecular Oral Microbiology·George Hajishengallis
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Helieh S Oz, David A Puleo
Nov 6, 2009·Journal of Dental Research·G PellegriniW V Giannobile
Mar 5, 2010·Journal of Dental Research·S C Kachlany
Mar 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Rui LiuLu-chuan Liu
Sep 6, 2008·Journal of Periodontology·Jean-David SebaounDonald J Ferguson
Aug 5, 2010·Journal of Periodontology·Helen SchreinerDaniel H Fine
Oct 5, 2011·Journal of Periodontology·Luciana S Branco-de-AlmeidaPedro L Rosalen
Jun 29, 2013·Journal of Periodontology·Rafael Scaf de MolonJoni Augusto Cirelli
May 3, 2013·Journal of Periodontology·Leticia ReyesAnn Progulske-Fox
May 3, 2013·Journal of Periodontology·Thomas E Van Dyke, Arie Jan van Winkelhoff
May 7, 2011·Journal of Oral Microbiology·Dana T GravesGustavo P Garlet
Oct 30, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrew J GlowackiSteven R Little
Aug 21, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y ZhouH Wang
Feb 8, 2014·Journal of Periodontology·Flávia A C FurlanetoMichel R Messora
Dec 3, 2014·International Immunopharmacology·Ying JinXiaoping Lin
Jul 23, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Hsiao-Pei TuEarl Fu
Apr 14, 2015·Periodontology 2000·Alpdogan KantarciThomas E Van Dyke
Apr 14, 2015·Periodontology 2000·Anton SculeanWilliam V Giannobile
Dec 24, 2015·American Journal of Obstetrics and Gynecology·Mariana Fampa FogacciAnna Thereza Thomé Leão
Nov 17, 2015·Animals : an Open Access Journal From MDPI·Jennifer H Wilson-WelderJarlath E Nally
Apr 29, 2014·Journal of Endodontics·Manuella Verdinelli de Paula ReisCarlos José Soares
Apr 29, 2015·Journal of Periodontal Research·V G GarciaL H Theodoro
May 25, 2012·Annales de cardiologie et d'angéiologie·V Blasco-BaqueR Burcelin
May 23, 2012·Thrombosis Research·Alice AssingerIvo Volf
Jul 6, 2010·Biochemical Pharmacology·George Hajishengallis
Jul 23, 2015·Journal of Periodontal Research·X DuanS Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.