The use of runs of homozygosity for estimation of recent inbreeding in Holstein cattle

Journal of Applied Genetics
Artur GurgulMonika Bugno-Poniewierska

Abstract

Controlling inbreeding in livestock populations is of great importance because excess relatedness among animals leads to a rapid loss of genetic variation and to adverse phenotypical effects associated with an inbreeding depression. Recent advances in genotyping technology have made it possible to study inbreeding at a molecular level by the analysis of genome-wide single nucleotide polymorphism panels. In this study, we used BovineSNP50 assay (Illumina) to estimate genomic inbreeding coefficient in 298 Holstein cattle by the analysis of the genome portion in runs of homozygosity (FROH) or using genomic relationship matrix (FGRM), and compared this data with conventional pedigree-based inbreeding coefficients (FPED). Weak or moderate Spearman's rank correlations were observed between FROH and FPED which depended on the ROH length categories used for calculations and inclusion of animals with different number of complete generations registered in pedigrees. The highest correlations were observed when using ROH with lengths over 8 Mb (0.334). The correlations tended to increase as pedigree depth increased, and were the highest for animals with seven complete generations of pedigree data. FGRM correlated poorly with pedigree-based...Continue Reading

References

Sep 2, 2008·American Journal of Human Genetics·Ruth McQuillanJames F Wilson
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Citations

Nov 9, 2017·Genetics, Selection, Evolution : GSE·Heidi Signer-HaslerChristine Flury
Dec 2, 2017·BMC Genomics·Alexandra BlantTrevor J Pemberton
Dec 24, 2017·Genetics, Selection, Evolution : GSE·Marina SoléTom Druet
Nov 23, 2017·Polish Journal of Veterinary Sciences·S KamińskiA Ruść
Oct 12, 2018·Journal of Animal Science·Pattarapol SumreddeeRomdhane Rekaya
Aug 10, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Elisa PeripolliFernando Baldi
Jan 21, 2020·Reproduction in Domestic Animals = Zuchthygiene·Alejandra Maria Toro OspinaJosineudson Augusto Ii de Vasconcelos Silva
Sep 20, 2020·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Wellington Bizarria Dos SantosRogério Abdallah Curi
May 6, 2020·Genes·Grazyella M YoshidaJosé M Yáñez
Nov 30, 2019·Animals : an Open Access Journal From MDPI·Tomasz SzmatołaMonika Bugno-Poniewierska
Jan 11, 2018·BMC Genomics·Elisa PeripolliMarcos Vinícius Gualberto Barbosa da Silva
Nov 13, 2020·Journal of Animal Science·Pattarapol SumreddeeRomdhane Rekaya
Oct 1, 2021·Animal Biotechnology·Abbas HajihosseinloSeyed Reza Miraei-Ashtiani

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