PMID: 9179426May 1, 1997Paper

The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A M WeverJ Hermans

Abstract

Corticosteroid therapy has become the mainstay in the treatment of asthma. However, the risk-benefit balance in the patient calls for assessment of the state of inflammation in the airways. In this respect serum eosinophil cationic protein (ECP) might be a marker, which can easily be measured in a clinical setting. Studies have indicated a relation between level of serum ECP and activity and severity in asthma. To investigate the feasibility to guide steroid therapy on the basis of the level of serum ECP in patients with chronic asthma. Twenty adult patients on maintenance inhaled steroid therapy visited the chest clinic once every 2 months over a 12-month period. At each visit a short history, blood sample for ECP and number of eosinophils, baseline spirometry, and histamine inhalation provocation test (PC20) were obtained. On the basis of level of ECP, adjustments in daily dose of steroids were considered. Data were compared with those of a previous 6-month ECP evaluation study in these same patients. In 10 patients mean dose of inhaled steroids was decreased > or = 25%. ECP rose slightly (antilogged mean from 9.06 to 11.8 micrograms/L) and lung function decreased slightly (mean FEV1 %predicted from 85.5 to 81.6). In seven pa...Continue Reading

Citations

May 17, 2000·Current Opinion in Pulmonary Medicine·A Niimi, H Matsumoto
Mar 24, 2010·Atherosclerosis·Giampaolo NiccoliFilippo Crea
Jul 15, 2005·Pediatric Pulmonology·Neal JainJoseph D Spahn
Feb 1, 2000·Respiratory Medicine·O Löwhagen
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P VengeA Trulson
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J C Kips, R A Pauwels

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