The use of solubility, dialyzability, and Caco-2 cell methods to predict iron bioavailability

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
Susan Fairweather-TaitRay Glahn

Abstract

An update on in vitro methods employed to assess iron bioavailability is presented. Solubility and dialyzability are not useful predictors of iron absorption, whereas Caco-2 cell models provide useful comparisons on the availability of iron from different sources. Strengths and weaknesses of in vitro approaches are briefly described, including the need to characterize Caco-2 cells in order to interpret results correctly. Further developments are required to refine Caco-2 model systems, including optimization and standardization of methods.

Citations

Sep 10, 2013·International Journal of Pharmaceutics·M Gulrez ZariwalaDerek Renshaw
Apr 29, 2009·World Journal of Gastroenterology : WJG·Carmen FrontelaCarmen Martínez
Dec 18, 2013·Colloids and Surfaces. B, Biointerfaces·M Gulrez ZariwalaDerek Renshaw
Sep 14, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Anne D Sørensen, Klaus Bukhave
Jun 9, 2016·The British Journal of Nutrition·Colin I CercamondiDiego Moretti
Aug 20, 2009·Food and Nutrition Bulletin·Mercy G Lung'aho, Raymond P Glahn
Aug 29, 2018·Journal of Food Science and Technology·Rateesh Krishnan, M S Meera

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