The Use of Stem Cell Therapy to Reverse Opioid Tolerance

Clinical Pharmacology and Therapeutics
Fei LiJianguo Cheng

Abstract

Opioid tolerance (OT) and opioid-induced hyperalgesia (OIH) are major challenges in medicine. Here we report that transplantation of mesenchymal stem cells (MSCs) prevented and reversed OT and OIH in rats and mice. The preventive and therapeutic effects were long-lasting and consistent across different assessment schemes. Both intrathecal and intravenous transplantations were effective and safe. This emerging therapeutic strategy has thus shown promise to impact clinical practice and improve the efficacy and safety of opioid therapy.

References

Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joyce A DeLeoVivianne L Tawfik
Jan 8, 2013·Nature Neuroscience·Francesco FerriniYves De Koninck
Aug 25, 2016·Scientific Reports·Zhen HuaJianguo Cheng
Jul 7, 2017·MMWR. Morbidity and Mortality Weekly Report·Gery P GuyDeborah Dowell

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Citations

May 18, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Tim J Lamer
Apr 7, 2020·The Journal of Clinical Investigation·Thomas BuchheitRu-Rong Ji
Jun 8, 2018·Clinical Pharmacology and Therapeutics·Rachel F Tyndale, Edward M Sellers
Aug 21, 2020·Pharmaceutical Patent Analyst·Hermann Am Mucke

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