The Use of Stem Cells in Neural Regeneration: A Review of Current Opinion

Current Stem Cell Research & Therapy
Yuhao WangJiyuan Liu

Abstract

Nerve injury is a large problem that produces much pain in patients. Injury to the nervous system causes serious consequences and affects a person's quality of life. The development of tissue engineering has created a brighter future for nerve regeneration, and research has not stopped since the discovery of stem cells. Stem cells are a type of pluripotent cell that exhibits the capacity of selfdifferentiation and proliferation. Many studies have demonstrated the ability of stem cells to differentiate into other types of cells, including neurons, after induction with trophic factors in vivo and in vitro. Scientists have isolated a variety of stem cells from different organs and tissues in the human body and demonstrated that these cells were efficacious in regenerative medicine. The use of these cells provides a non-surgical method for the treatment of neurological diseases, such as nerve defects. However, many problems must be resolved before using these cells in the clinical field. The microenvironment and delivery methods of cells also affect the regeneration process. The present article comprehensively summarizes the progress of stem cells in the field of nerve regeneration in the recent decades.

Citations

Jun 2, 2020·Anatomical Science International·Ahmed Othman Fathy Othman El-KershRasha H Al-Serwi
Feb 9, 2020·Biochemical and Biophysical Research Communications·Rouhollah HabibeyVolker Busskamp
Apr 12, 2020·Journal of Chemical Neuroanatomy·Nourollah RezaeiHatef Ghasemi Hamidabadi
Apr 9, 2021·Stem Cell Reviews and Reports·Vincenzo MatteiSimona Delle Monache
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Fernando José Rascón-RamírezLeyre Sánchez-Sánchez-Rojas

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