The use of stereotactic body radiation therapy in gastrointestinal malignancies in locally advanced and metastatic settings

Clinical Colorectal Cancer
Polina KhrizmanAl B Benson

Abstract

Gastrointestinal (GI) malignancies are a major cause of cancer morbidity and mortality, with an estimated 275,720 cases and 135,800 deaths in 2009. Treatment of GI malignancies presents a challenge both in the localized and metastatic setting and in formulating new ways to improve local disease control and ultimately overall survival. Among conventional modalities of treatment, such as systemic chemotherapy, fractionated radiation therapy, surgical resection, and nonsurgical invasive means, a new technology has emerged: stereotactic body radiation therapy (SBRT). Its origins stem from the intracranial stereotactic radiosurgery developed in 1950s for the treatment of patients with intracranial malignancies. SBRT is a new and innovative way of delivering high-dose radiation to the extracranial tumor targets in one or few fractions with a high degree of precision. Although SBRT technology such as CyberKnife and Novalis are becoming increasingly popular and widely used, there are limited data that provide comparison with conventional therapy, and no randomized, prospective, multicenter studies that having been conducted in areas of GI malignancies. Current studies that provide data on SBRT use consist of small cohorts of patients, ...Continue Reading

References

Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ryusuke HaraTakaaki Kobiki
Apr 10, 2003·The Annals of Thoracic Surgery·Richard I WhyteQuynh-Thu Le
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Rikiya OnimaruHirotoshi Dosaka-Akita
May 9, 2003·Surgical Oncology Clinics of North America·Reza KianmaneshJacques Belghiti
May 10, 2003·International Journal of Radiation Oncology, Biology, Physics·Holger HofJürgen Debus J
Jun 5, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sang-wook LeeByong Yong Yi
Mar 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Albert C KoongJ Augusto Bastidas
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Joern WulfMichael Flentje
Nov 3, 2004·International Journal of Radiation Oncology, Biology, Physics·Louis PottersUNKNOWN American College of Radiology
Jul 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Morten HoyerHans von der Maase
Sep 20, 2006·Acta Oncologica·Morten HoyerHans Von der Maase
Sep 20, 2006·Acta Oncologica·Joern WulfMichael Flentje
Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Dec 6, 2006·Surgical Neurology·David W AndrewsBeverly Downes
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Quynh-Thu LeJessica Donington
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael G HaddockSteven R Alberts
Jan 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Regina V TseLaura A Dawson
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William SmallCornelius J McGinn
Apr 9, 2008·International Journal of Radiation Oncology, Biology, Physics·Devin SchellenbergAlbert C Koong
Aug 30, 2008·Japanese Journal of Clinical Oncology·Mi-Sook KimHyeJeong Kang
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kyle E RusthovenTracey E Schefter
Apr 15, 2009·CA: a Cancer Journal for Clinicians·Robert D TimmermanDavid Lu
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher H CraneChristopher G Willett
Sep 15, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Iris C GibbsAlbert Koong
Oct 21, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra L WongAl B Benson

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Citations

Mar 23, 2011·Future Oncology·Autumn J McReeRichard M Goldberg
Oct 20, 2012·International Journal of Radiation Oncology, Biology, Physics·Sun Hyun BaeSang Bum Kim
Jan 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sun Hyun BaeSunmi Jo
Jul 3, 2018·Nursing Standard·Jacquie Peck
Jun 19, 2013·International Journal of Colorectal Disease·Sun Hyun BaeSang Bum Kim
May 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeho JeongJoseph O Deasy

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