The use of stereotactic radiosurgery to treat intractable childhood partial epilepsy

Epilepsia
Catalina DunoyerMichael Duchowny

Abstract

Although conventional surgery is presently used to treat seizures of temporolimbic and neocortical origin, deep-seated lesions are often associated with morbidity. Stereotactic radiosurgery is a noninvasive procedure that effectively treats patients with vascular malformations and brain tumors, but its efficacy for epileptogenic foci is limited, especially in children. Between 1995 and 1999, four candidates who had medically uncontrolled seizures and localized seizure foci were selected for stereotactic radiosurgery, with a mean age of 9.75 years at the time of surgery (range, 4-17 years). Seizure foci were identified on the basis of ictal and interictal video-EEG. Magnetic resonance (MR) images were obtained before and after surgery. Ictal single-photon emission computed tomography (SPECT) was performed by using stabilized hexamethyl-propyleneamine oxime (HMPAO; 300 microcuries/kg) with early injection after electrographic ictal onset. The clinical features of the patients are given. All radiosurgical procedures were performed with the gamma knife unit with the Leksell stereotactic frame, stereotactic MRI imaging, and the Gamma Plan workstation. Seizure outcome was scored according to Engel's classification. Two patients had h...Continue Reading

References

Jan 1, 1992·Acta neurochirurgica·E R HeikkinenK Sotaniemi
Jan 1, 1991·Stereotactic and Functional Neurosurgery·C LindquistE Hellstrand
Jan 1, 1987·Applied Neurophysiology·J L Barcia-SalorioL López-Gómez
Jan 1, 1985·Applied Neurophysiology·J L Barcia SalorioL Lopez Gomez
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·C MunariO O Betti
Jan 1, 1995·Stereotactic and Functional Neurosurgery·C J Whang, C J Kim
Jan 1, 1996·Stereotactic and Functional Neurosurgery·J RégisJ C Peragut
Jan 1, 1996·Stereotactic and Functional Neurosurgery·C J Whang, Y Kwon
Jul 1, 1997·Annals of Neurology·R KuznieckyH G Liu
Mar 4, 1998·Annals of Neurology·S M SisodiyaS D Shorvon
Oct 23, 1998·Stereotactic and Functional Neurosurgery·O SchröttnerG Pendl
Feb 13, 1999·Mayo Clinic Proceedings·B E PollockR W Kline
Feb 13, 1999·Mayo Clinic Proceedings·L D Lunsford
Nov 24, 1999·Epilepsia·J RégisJ C Peragut
Feb 19, 2000·Neurology·J M PaolicchiM Duchowny
Feb 22, 2000·Stereotactic and Functional Neurosurgery·Y Régis, D W Roberts
Jun 12, 2001·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C MottoleseC Lapras

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Citations

Sep 11, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M AndrewM A McShane
Jan 21, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·James L FrazierGeorge I Jallo
Jul 16, 2003·Epilepsia·Philippe Ryvlin
Jun 23, 2006·Stereotactic and Functional Neurosurgery·David MathieuL Dade Lunsford
Apr 22, 2009·European Journal of Medical Research·Jan VesperG Lammering
May 26, 2005·Neurologia Medico-chirurgica·Kazunori AritaHiroshi Otsubo
Jun 4, 2013·Neurosurgical Focus·Sandeep MittalFrederick Andermann
Jun 4, 2013·Neurosurgical Focus·Sandeep MittalFrederick Andermann
May 2, 2008·Neurosurgical Focus·Pantaleo RomanelliSalvatore Striano
Jun 5, 2007·Seminars in Pediatric Neurology·Jean RégisPatrick Chauvel
Jun 5, 2007·Seminars in Pediatric Neurology·Yu-tze Ng, Harold L Rekate
Sep 1, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jeffrey V RosenfeldA Simon Harvey
Jun 20, 2006·Lancet Neurology·Pantaleo Romanelli, David J Anschel
Aug 24, 2005·Seminars in Pediatric Neurology·John F KerriganHarold L Rekate
Feb 9, 2017·Neurosurgical Review·S ChibbaroF Proust

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