The use of surgery in the treatment of ER+ early stage breast cancer in England: Variation by time, age and patient characteristics

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
P RichardsLynda Wyld

Abstract

To assess whether the proportion of patients aged 70 and over with ER+ operable breast cancer in England who are treated with surgery has changed since 2002, and to determine whether age and individual level factors including tumour characteristics and co-morbidity influence treatment choice. A retrospective cohort analysis of routinely collected cancer registration data from two English regions (West Midlands, Northern & Yorkshire) was carried out (n = 17,129). Trends in surgical use over time for different age groups were assessed graphically and with linear regression. Uni- and multivariable logistic regressions were used to assess the effects of age, comorbidity, deprivation and disease characteristics on treatment choice. Missing data was handled using multiple imputation. There is no evidence of a change in the proportion of patients treated surgically over time. The multivariable model shows that age remains an important predictor of whether or not a woman with ER+ operable breast cancer receives surgery after covariate adjustment (Odds ratio of surgery vs no surgery, 0.82 (per year over 70)). Co-morbidity, deprivation, symptomatic presentation, later stage at diagnosis and low grade are also associated with increased pr...Continue Reading

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Citations

Mar 21, 2006·The International Journal of Biochemistry & Cell Biology·Sinan BattahAlexander J MacRobert
Aug 10, 2017·Oncology Letters·Fuqian YangNana Zhao
Dec 4, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Yasmin JauhariDavid Alan Cromwell
Mar 13, 2021·The British Journal of Surgery·Y JauhariD A Cromwell
Apr 1, 2021·Medicine·Shipei WangLiang Guo
Feb 16, 2019·Soins. Gérontologie·Laetitia Daubisse-MarliacRosine Guimbaud
May 28, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·S E WardL Wyld

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