The use of system identification techniques in the analysis of oculomotor burst neuron spike train dynamics

Journal of Computational Neuroscience
Kathleen E CullenHenrietta L Galiana

Abstract

The objective of system identification methods is to construct a mathematical model of a dynamical system in order to describe adequately the input-output relationship observed in that system. Over the past several decades, mathematical models have been employed frequently in the oculomotor field, and their use has contributed greatly to our understanding of how information flows through the implicated brain regions. However, the existing analyses of oculomotor neural discharges have not taken advantage of the power of optimization algorithms that have been developed for system identification purposes. In this article, we employ these techniques to specifically investigate the "burst generator" in the brainstem that drives saccadic eye movements. The discharge characteristics of a specific class of neurons, inhibitory burst neurons (IBNs) that project monosynaptically to ocular motoneurons, are examined. The discharges of IBNs are analyzed using different linear and nonlinear equations that express a neuron's firing frequency and history (i.e., the derivative of frequency), in terms of quantities that describe a saccade trajectory, such as eye position, velocity, and acceleration. The variance accounted for by each equation can...Continue Reading

References

Mar 30, 1976·Biological cybernetics·A C Sanderson, B Kobler
May 22, 1992·Annals of the New York Academy of Sciences·H L Galiana, D Guitton
Apr 1, 1990·Journal of Neurophysiology·C M HarrisC A Scudder
Jan 1, 1989·Experimental Brain Research·T VillisV Henn
May 1, 1988·Journal of Neurophysiology·C A Scudder
Dec 1, 1987·British Journal of Haematology·A WallmarkI M Nilsson
Mar 1, 1986·The Journal of Physiology·G CheronB Vanderkelen
Mar 1, 1986·The Journal of Physiology·G CheronE Godaux
May 1, 1987·Journal of Neurophysiology·S C Cannon, D A Robinson
Jul 15, 1986·The Journal of Comparative Neurology·A StrassmanR A McCrea
Jul 15, 1986·The Journal of Comparative Neurology·A StrassmanR A McCrea
Jan 1, 1985·Annual Review of Neuroscience·A F FuchsC A Scudder
Jan 1, 1985·Experimental Brain Research·A Grantyn, A Berthoz
Jan 1, 1985·Vision Research·A J Van OpstalJ J Eggermont
Oct 1, 1985·Journal of Neurophysiology·L M Optican, F A Miles
May 1, 1970·Journal of Neurophysiology·D A Robinson
Nov 1, 1968·Biophysical Journal·B L ZuberL Stark
Dec 1, 1984·Journal of Neurophysiology·D GuittonM Volle
Jan 1, 1981·Annals of the New York Academy of Sciences·S Sasaki, H Shimazu
Jan 1, 1981·Annals of the New York Academy of Sciences·R BakerR A McCrea
Feb 1, 1982·Journal of Neurophysiology·J Lopez-BarneoR Baker
Mar 1, 1981·Journal of Neurophysiology·J A Van GisbergenS Gielen
Jan 1, 1993·Biological cybernetics·C G Rey, H L Galiana
Nov 1, 1964·The Journal of Physiology·D A ROBINSON

❮ Previous
Next ❯

Citations

Sep 7, 2004·Experimental Brain Research·Americo A MigliaccioLloyd B Minor
Nov 18, 2005·Experimental Brain Research·Jay S PathmanathanDavid M Waitzman
Aug 6, 2010·Experimental Brain Research·N ShanidzeW M King
Feb 8, 2011·Experimental Brain Research·Jerome CarriotJ R Lackner
May 14, 2008·Journal of the Association for Research in Otolaryngology : JARO·David M LaskerLloyd B Minor
Dec 19, 2008·Journal of Neurophysiology·Soroush G SadeghiKathleen E Cullen
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mohsen JamaliKathleen E Cullen
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soroush G SadeghiKathleen E Cullen
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica X Brooks, Kathleen E Cullen
Oct 19, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soroush G SadeghiKathleen E Cullen
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jerome CarriotKathleen E Cullen
Jun 26, 2008·Journal of Neuroscience Methods·Sofiane CherifHenrietta L Galiana
Aug 4, 2009·Annals of the New York Academy of Sciences·Kathleen E CullenSoroush G Sadeghi
Nov 26, 2005·The Journal of Physiology·Jason A Cromer, David M Waitzman
May 21, 2013·Current Biology : CB·Jessica X Brooks, Kathleen E Cullen
May 10, 2016·Nature Communications·Diana E MitchellKathleen E Cullen
Nov 4, 2009·International Journal of Neural Systems·Wei ZhouJohn Enderle
Apr 13, 2013·International Journal of Neural Systems·John D Enderle, Daniel A Sierra
Jan 30, 2004·Journal of Neurophysiology·Seiji OnoMichael J Mustari
Apr 4, 2003·Journal of Neurophysiology·Pierre A SylvestreKathleen E Cullen
Mar 3, 2007·Journal of Neurophysiology·R A A VingerhoetsW P Medendorp
Mar 14, 2008·Journal of Neurophysiology·Marion R Van HornKathleen E Cullen
Jul 18, 2008·Journal of Neurophysiology·Marion R Van Horn, Kathleen E Cullen
Dec 23, 2008·Experimental Physiology·Alistair A Young, Alejandro F Frangi
Oct 4, 2013·Journal of Neurophysiology·Ioana Medrea, Kathleen E Cullen
Dec 6, 2002·Journal of Neurophysiology·Pierre A Sylvestre, Kathleen E Cullen
May 1, 2009·Journal of Neurophysiology·Marion R Van Horn, Kathleen E Cullen
Apr 27, 2002·Journal of Neurophysiology·Jefferson E Roy, Kathleen E Cullen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.