PMID: 2896248Feb 1, 1988Paper

The use of testicular volume as a clinical marker for cytogenetic disorders in mentally retarded males

Journal of Mental Deficiency Research
A J KirkilionisF R Sergovich


The testicular volumes (V) of 817 adult (non-Down's syndrome) institutionalized males were calculated. The mean testicular volume was 19.5 +/- 15.8 ml, comparable to the normal adult male mean of 17-19 ml. However, the number of institutionalized males with V greater than or equal to 25 ml and V less than or equal to 10 ml was increased approximately fourfold over the normal male population. Resident adult males were grouped into three categories based on their testicular volumes: (1) V greater than or equal to 25 ml (macro-orchid); (2) V less than or equal to 15 ml (micro-orchid); and (3) 15 less than V less than 25 ml ('normal'). An equal number of randomly selected males from each category were cytogenetically screened for the fra(X) syndrome as well as for non-fra(X) chromosome abnormalities. The overall frequencies of these disorders were 3.1% and 3.9%, respectively. The fra(X) syndrome was found in a significantly higher percentage of macro-orchid males (10.3%) as compared to males with either micro-orchidism (1.2%) or normal testicular volume (1.2%). There was no significant difference in the distribution of either fra(X) negative non-specific XLMR or non-fra(X) chromosome abnormalities among resident males from these th...Continue Reading


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