The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer

Frontiers in Immunology
Mayra A CarrilloScott Kitchen

Abstract

HIV and cancer remain prevailing sources of morbidity and mortality worldwide. There are current efforts to discover novel therapeutic strategies for the treatment or cure of these diseases. Humanized mouse models provide the investigative tool to study the interaction between HIV or cancer and the human immune system in vivo. These humanized models consist of immunodeficient mice transplanted with human cells, tissues, or hematopoietic stem cells that result in reconstitution with a nearly full human immune system. In this review, we discuss preclinical studies evaluating therapeutic approaches in stem cell-based gene therapy and T cell-based immunotherapies for HIV and cancer using a humanized mouse model and some recent advances in using checkpoint inhibitors to improve antiviral or antitumor responses.

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Citations

Nov 27, 2018·ILAR Journal·Nana H OvergaardGregers Jungersen
Jun 18, 2019·Lupus Science & Medicine·Mary K Crow, Lars Ronnblom
Feb 23, 2019·Infectious Agents and Cancer·Alberto RealeGiorgio Palù
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Sep 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Keke LiangCaius G Radu

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Methods Mentioned

BETA
genetic modification
transgenic
genetic

Clinical Trials Mentioned

NCT01734850

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