The use of the rat as a model for studying peripheral nerve regeneration and sprouting after complete and partial nerve injuries

Experimental Neurology
Tessa Gordon, Gregory H Borschel

Abstract

Rat models of complete and partial injuries are the most frequently used models for analysis of the cellular and molecular processes of nerve regeneration and axon sprouting. Studies of nerve regeneration and axon sprouting after complete and partial nerve injuries, respectively, are reviewed. Special consideration is made of the peripheral nerves chosen for the studies and the outcome measures that were utilized in the studies. The studies have made important contributions to our knowledge of the degenerative and regenerative processes that occur after the peripheral nerve injuries, why functional recovery is frequently compromised after delayed surgery, the positive effects of neurotrophic factors on nerve regeneration after delayed nerve repair or after insertion of autografts between transected nerve, and how axon regeneration may be accelerated by brief periods of electrical stimulation and/or by administration of androgens.

References

Jun 1, 1979·Scientific American·R Levi-Montalcini, P Calissano
Oct 1, 1990·Annals of Neurology·J F YangT Gordon
Sep 1, 1989·Journal of the Neurological Sciences·R Pamphlett
Aug 1, 1987·Experimental Neurology·T M Brushart, W A Seiler
Mar 1, 1986·The Journal of Physiology·M J GillespieP R Murphy
Aug 30, 1985·Neuroscience Letters·S Pockett, R M Gavin
Feb 1, 1974·The Journal of Physiology·R Jones, G Vrbová
Oct 1, 1984·Journal of Neurocytology·W Beuche, R L Friede
May 1, 1983·Muscle & Nerve·J R SlackS Pockett
Jan 1, 1981·Annual Review of Neuroscience·M C BrownW G Hopkins
Dec 7, 1981·Brain Research·J R Slack, M N Williams
Sep 1, 1980·The Journal of Physiology·M C BrownR Ironton
Jan 1, 1995·Neuron·Y J Son, W J Thompson
Feb 1, 1994·Neuron·J GeorgiouM P Charlton
Apr 1, 1994·Pharmacology & Therapeutics·D N IshiiS F Pu
Mar 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·V M VergeP M Richardson
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Nov 22, 2000·Experimental Neurology·S G SiegelA W English
Nov 21, 2001·Nature Reviews. Neuroscience·J R Sanes, J W Lichtman

❮ Previous
Next ❯

Citations

Nov 25, 2017·Neural Regeneration Research·Carolyn Tallon, Mohamed H Farah
Aug 9, 2018·Neurological Research·Ramazan ÜstünHasan Korkaya
Aug 15, 2018·Neurological Research·Diana CostaArtur S P Varejão
Jul 19, 2019·Journal of Exercise Rehabilitation·Marcílio Coelho FerreiraAna Paula Santos
Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Maliheh JahromiAbbas Bakhtiari
Sep 7, 2019·Plastic and Reconstructive Surgery·Alessandra Grassi SallesRolf Gemperli
Sep 25, 2020·Journal of Reconstructive Microsurgery·James M KernsMark H Gonzalez
Mar 21, 2019·Acta Cirúrgica Brasileira·Danusa Neves SomensiRui Sergio Monteiro de Barros
Oct 15, 2019·Frontiers in Cellular Neuroscience·Quanpeng ZhangXinan Yi
Jan 23, 2019·Frontiers in Cellular Neuroscience·Tessa GordonOlawale A R Sulaiman
Dec 12, 2018·Neural Regeneration Research·Martial CaillaudFabrice Billet
Jul 19, 2019·Frontiers in Cellular Neuroscience·Takeshi EndoNorimasa Iwasaki
Apr 3, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Carolyn TallonMohamed H Farah
Nov 26, 2019·Plastic and Reconstructive Surgery·Alessandra Grassi SallesRolf Gemperli
Nov 10, 2020·Tissue Engineering. Part a·Meer N AhmedFatima N Syed-Picard
Jan 21, 2021·Cell and Tissue Research·N Nieto-NicolauA Vilarrodona
Jan 30, 2021·Microsurgery·Anthony DeLeonibusBahar Bassiri Gharb
Nov 21, 2020·International Journal of Molecular Sciences·Tessa Gordon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

© 2022 Meta ULC. All rights reserved