The use of the RenalGuard system in cardiac surgery with cardiopulmonary bypass: a first in man prospective, observational, feasibility pilot study

Open Heart
Heyman LuckrazAlan Nevill

Abstract

As proof of concept, this prospective, observational study assessed the feasibility and early clinical outcomes of performing on-pump cardiac surgery with the RenalGuard system. Acute kidney injury (AKI) is reported in up to 30% of patients undergoing cardiac surgery and is a recognised independent predictor of both morbidity and mortality. Forced diuresis with the RenalGuard system reduces the incidence of AKI during percutaneous coronary intervention procedures but its use in cardiac surgery has not been explored. Ten consecutive patients who were at risk of developing AKI during cardiac surgery were selected. The RenalGuard system was used to facilitate forced diuresis using weight-adjusted intravenous furosemide while maintaining neutral fluid balance by matched intravenous fluid replacement. This regimen was initiated preoperatively in all patients and continued for 6-12 hours postoperatively. Serum creatinine, electrolytes and need for renal replacement were documented in all patients. The RenalGuard system functioned successfully in all patients and facilitated high perioperative urine outputs, even when patients were placed on cardiopulmonary bypass (CPB). There were no incidences of significant (A) electrolyte imbalanc...Continue Reading

Citations

Dec 19, 2019·Frontiers in Pediatrics·Catherine D Krawczeski
Nov 26, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Heyman LuckrazAlan Nevill
Jun 26, 2021·KI Reports·Keyvan Karimi GalougahiZiad A Ali
Jul 31, 2019·Kidney & Blood Pressure Research·Daniel PatschanOliver Ritter

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Methods Mentioned

BETA
urine collection
coronary artery bypass

Clinical Trials Mentioned

NCT02974946

Software Mentioned

RenalGuard

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