The use of tissue plasminogen activator as continuous infusion into an arteriovenous hemodialysis access in the hemodialysis unit: a case series

Canadian Journal of Kidney Health and Disease
Elene van der MerweMercedeh Kiaii

Abstract

Thrombolytics such as tissue plasminogen activator are often used by interventional radiologists in the radiology suite to salvage thrombosed hemodialysis arteriovenous fistulae. Thrombolytics are also commonly used in dialysis facilities as a dialysis catheter lock solution or as an infusion into a dialysis catheter when dysfunctional. However, the use of tissue plasminogen activator as a continuous infusion into an arteriovenous fistula in the dialysis facility to treat clot burden is not commonly done. The aim of our case series is to demonstrate the successful use of tissue plasminogen activator to decrease clot burden in an arteriovenous fistula in the dialysis unit. Observational case series. An outpatient dialysis facility in a tertiary care hospital. Three non- consecutive patients were diagnosed with an acute thrombosed arteriovenous fistula either on physical exam or by imaging. A thrombosed fistula as well as successful resolution of clot was illustrated by either physical exam, fistulogram or ultrasound. A functioning fistula demonstrated successful continuation of dialysis and adequate access flow measurements in follow up. This is a case series that describes the technique of using an infusion of tissue plasminoge...Continue Reading

References

Oct 6, 1997·Journal of Vascular and Interventional Radiology : JVIR·J CynamonS Sprayregen
Apr 5, 2001·Journal of Vascular and Interventional Radiology : JVIR·A FalkJ Vassalotti
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Citations

Dec 31, 2019·BMC Medical Research Methodology·Allison TongJonathan C Craig
Dec 17, 2020·Neurological Research and Practice·Loraine BusettoChristoph Gumbinger

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