The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL)

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Ivan V LitvinovThomas S Kupper

Abstract

Although many patients with mycosis fungoides presenting with stage I disease enjoy an indolent disease course and normal life expectancy, about 15% to 20% of them progress to higher stages and most ultimately succumb to their disease. Currently, it is not possible to predict which patients will progress and which patients will have a stable disease. Previously, we conducted microarray analyses with RT-PCR validation of gene expression in biopsy specimens from 60 patients with stage I-IV cutaneous T-cell lymphoma (CTCL), identified three distinct clusters based upon transcription profile, and correlated our molecular findings with 6 years of clinical follow-up. We test by RT-PCR within our prediction model the expression of about 240 genes that were previously reported to play an important role in CTCL carcinogenesis. We further extend the clinical follow-up of our patients to 11 years. We compare the expression of selected genes between mycosis fungoides/Sézary syndrome and benign inflammatory dermatoses that often mimic this cancer. Our findings demonstrate that 52 of the about 240 genes can be classified into cluster 1-3 expression patterns and such expression is consistent with their suggested biologic roles. Moreover, we d...Continue Reading

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Citations

Dec 16, 2017·Journal of Cutaneous Medicine and Surgery·Feras M GhazawiIvan V Litvinov
Mar 20, 2018·Melanoma Research·Patrick NasarreNancy Klauber-DeMore
Feb 8, 2018·Frontiers in Oncology·Taku FujimuraSetsuya Aiba
Nov 18, 2017·Expert Opinion on Therapeutic Targets·Anna OrlovaRichard Moriggl
Feb 11, 2020·Frontiers in Oncology·Ritika Walia, Cecilia C S Yeung
Nov 5, 2019·Archives of Dermatological Research·Jingkai XuYaohua Zhang
Apr 20, 2018·Blood Advances·Anita KumarSteven M Horwitz
Apr 17, 2020·Frontiers in Medicine·Arieh GomolinIvan V Litvinov
Jan 1, 2021·Cancer Science·Noriko Hosoya, Kiyoshi Miyagawa
Jan 15, 2021·World Neurosurgery·Guorong YangLing Qin
Feb 8, 2018·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Guoting JiangYunqiu Yu
Apr 29, 2021·Seminars in Hematology·John C Reneau, Ryan A Wilcox
May 11, 2018·Science Translational Medicine·Adele de MassonThomas S Kupper

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