The use of transgenic mice for modeling airways disease

Pulmonary Pharmacology & Therapeutics
Steven D Shapiro

Abstract

Genetic manipulation in mice often combined with models of human disease has allowed investigators to dissect specific disease pathways. These tools have taught us much about the pathogenesis of chronic obstructive pulmonary disease (COPD). In particular, we have defined a complex inflammatory-protease network leading to emphysema. Translation of these findings to humans requires careful interpretation of the strengths and limitations of the models as well as similarities and differences between mouse and human biology.

References

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Citations

Apr 23, 2014·Expert Opinion on Drug Discovery·Luigino CalzettaMaria Gabriella Matera
Jul 5, 2011·Drug Discovery Today·Anthony M HolmesStephen T Holgate
Aug 13, 2015·Journal of Immunology Research·R Bonamichi-SantosP Giavina-Bianchi
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Nov 13, 2020·Clinical and Experimental Otorhinolaryngology·Roza Khalmuratova, Hyun-Woo Shin

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