The use of transgenic parasites in malaria vaccine research

Expert Review of Vaccines
Ahmad Syibli OthmanShahid M Khan

Abstract

Transgenic malaria parasites expressing foreign genes, for example fluorescent and luminescent proteins, are used extensively to interrogate parasite biology and host-parasite interactions associated with malaria pathology. Increasingly transgenic parasites are also exploited to advance malaria vaccine development. Areas covered: We review how transgenic malaria parasites are used, in vitro and in vivo, to determine protective efficacy of different antigens and vaccination strategies and to determine immunological correlates of protection. We describe how chimeric rodent parasites expressing P. falciparum or P. vivax antigens are being used to directly evaluate and rank order human malaria vaccines before their advancement to clinical testing. In addition, we describe how transgenic human and rodent parasites are used to develop and evaluate live (genetically) attenuated vaccines. Expert commentary: Transgenic rodent and human malaria parasites are being used to both identify vaccine candidate antigens and to evaluate both sub-unit and whole organism vaccines before they are advanced into clinical testing. Transgenic parasites combined with in vivo pre-clinical testing models (e.g. mice) are used to evaluate vaccine safety, pot...Continue Reading

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Citations

Apr 4, 2020·PLoS Neglected Tropical Diseases·Canhui LiuThomas R Unnasch
Sep 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Talha Bin EmranShigeto Yoshida
Aug 30, 2019·Nature Reviews. Immunology·Jean-Philippe Julien, Hedda Wardemann
Aug 4, 2018·Frontiers in Cellular and Infection Microbiology·Ahmad Syibli OthmanShahid M Khan
Sep 28, 2018·Current Medicinal Chemistry·María ValenteDolores González-Pacanowska
May 7, 2019·Frontiers in Cellular and Infection Microbiology·Catherin Marin-MogollonShahid M Khan
Nov 11, 2019·Drug Discovery Today·Maria E SheeanVioleta Stoyanova-Beninska
Mar 18, 2020·Journal of Advanced Research·Arif Jamal SiddiquiWhitni Redman

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