The use of URYX for reversible vasectomy in a rabbit model

Journal of Andrology
Cathy K NaughtonAnthony J Thomas

Abstract

URYX is a biocompatible polymer of ethylene vinyl alcohol dissolved in a dimethyl sulfoxide (DMSO) carrier to allow injection of a very low-viscosity fluid into tissue. Once the material comes into contact with body tissue or fluid, the DMSO rapidly dissipates from the polymer, which results in a precipitate of a coherent solid mass. The purpose of the present study was to determine whether URYX can effectively occlude the vas deferens and whether patency can be restored by redissolving the URYX in vivo using the solvent DMSO. Eight male New Zealand White rabbits (age range, 25-41 weeks; mean age, 33.9 +/- 7.5 weeks; mean weight, 4.0 +/- 0.2 kg) were used in 2 experiments (E1 and E2). In E1, 3 rabbits underwent unilateral vasectomy, and the contralateral vas was injected with either 0.05 or 0.10 mL of URYX, to determine the amount of URYX required to cause obstruction. Two animals underwent bilateral vasectomy, to serve as controls. In E2, 3 animals underwent bilateral URYX injection and were compared with the bilateral vasectomy control rabbits used in E1. After 1 month of initial bilateral URYX treatment, all animals in E2 underwent attempted unilateral reversal with 1.5 mL of DMSO injected into 1 occluded vas deferens. Two e...Continue Reading

References

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Sep 5, 2003·Journal of Andrology·Cathy K NaughtonAnthony J Thomas

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Citations

Oct 24, 2007·International Urogynecology Journal and Pelvic Floor Dysfunction·Annette KuhnAsh Monga
Apr 19, 2017·Basic and Clinical Andrology·Donald WallerGary Gamerman
Apr 4, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Anran XuXiaohui Deng
Jan 18, 2008·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Wilson F BusatoLuiz C Rocha

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