The usefulness of antithrombin activity monitoring during antithrombin supplementation in patients with sepsis-associated disseminated intravascular coagulation

Thrombosis Research
Toshiaki IbaJecko Thachil

Abstract

Recent studies have repeatedly reported the effectiveness of antithrombin (AT) supplementation for sepsis-associated disseminated intravascular coagulation (DIC). In this study, we intended to elucidate the usefulness of monitoring antithrombin activity during antithrombin supplementation. Data of 926 patients with sepsis-associated DIC who had been undergone AT substitution were retrospectively analyzed. All the patients had received 1500IU/day of AT concentrate for three consecutive days. The patients' demographic characteristics, including the age, body weight, baseline DIC score and baseline AT activity, and treatment-related markers such as the change in DIC score and the change in the AT activity with treatment were analyzed in relation to the 28-day mortality. Logistic regression analysis revealed a significant association of the patients' age, baseline AT activity, Δ AT activity, baseline DIC score and Δ DIC score to the patients' outcomes. The cutoff values of the AT activities for death calculated by the ROC curve analysis were 41.3% for the baseline AT activity, 72.9% for the post-treatment AT activity and 37.0% for Δ AT activity. The area under the ROC curve (AUC) showed discriminative powers for the baseline AT act...Continue Reading

References

Jun 17, 2005·Intensive Care Medicine·Mirka SivulaVille Pettilä
Mar 8, 2006·Critical Care Medicine·Satoshi GandoUNKNOWN Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group
Sep 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Christian J Wiedermann, Nicole C Kaneider
Oct 9, 2008·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Atsushi SawamuraMasahiro Sugano
Sep 29, 2009·Thrombosis Research·Hideo WadaUNKNOWN Japanese Society of Thrombosis Hemostasis/DIC subcommittee
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Dec 18, 2013·Critical Care : the Official Journal of the Critical Care Forum·Satoshi GandoUNKNOWN Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group for the JAAM DIC Antit
Sep 16, 2014·Critical Care : the Official Journal of the Critical Care Forum·Toshiaki IbaHidesaku Asakura

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Citations

Dec 18, 2015·Thrombosis and Haemostasis·Jerrold H LevyMarcel Levi
Dec 30, 2014·Internal and Emergency Medicine·Marcel Levi, Suthesh Sivapalaratnam
Sep 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Toshiaki IbaDaizoh Saitoh
Jun 26, 2015·Scientific Reports·Yuko KurosawaTakafumi Hamaoka
May 11, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Toshiaki IbaYasuhiro Kuroda
Jul 28, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Toshiaki IbaDaizoh Saitoh
Apr 1, 2016·Anesthesiology·Jecko Thachil
Feb 28, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Toshiaki IbaJerrold H Levy
May 1, 2020·Italian Journal of Pediatrics·Hayato GoMitsuaki Hosoya
May 1, 2021·International Journal of Molecular Sciences·Christine SchlömmerMirjam Bachler

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