The Usefulness of Defining Rapid Virological Response by a Very Sensitive Assay (TMA) during Treatment of HCV Genotype 2/3 Infection

PloS One
Olav DalgardPatrick Marcellin

Abstract

The aim of this study was to determine in patients with HCV genotype 2 or 3 the performance at week 4 of two assays with different sensitivities for HCV RNA detection, for the prediction of SVR and stratification for treatment duration (14 and 24 weeks). Recruitment was from two trials comparing 14 and 24 weeks treatment to patients with rapid virological response (RVR) (n = 550). RVR was originally defined as HCV RNA <50 IU/ml at week 4. Patients with an available frozen plasma sample drawn at week 4 and with follow-up data week 24 post-treatment were included (n = 429). HCV-RNA was prospectively measured with COBAS Amplicor V2, Roche (CA) (lower detection limit 50 IU/ml) and retrospectively assessed with VERSANT HCV-RNA Qualitative Assay, Siemens (TMA) (lower limit detection 10 IU/ml). Genotype 3 was present in 80% and genotype 2 in 20%. A SVR was achieved in 82%. At week 4 HCV-RNA was undetectable in 74.8% and 63% of serum samples tested with CA and TMA, respectively. CA undetectable/TMA positive was observed in 61/341 (18%) of the samples. In genotype 3 patients a relapse was seen in 9% of the patients with both CA and TMA undetectable and in 25% of the patients who were CA undetectable/TMA positive (p = 0.006). In patients...Continue Reading

References

Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Nov 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olav DalgardHelge Bell
Jun 24, 2005·The New England Journal of Medicine·Alessandra MangiaAngelo Andriulli
Jul 13, 2007·The New England Journal of Medicine·Mitchell L ShiffmanUNKNOWN ACCELERATE Investigators
Nov 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olav DalgardUNKNOWN North-C Group
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Sep 15, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Michelle Martinot-PeignouxPhilippe Halfon
Mar 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Moises DiagoDavid R Nelson
Mar 5, 2011·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Apr 28, 2012·Gastroenterology·Stéphane ChevaliezJean-Michel Pawlotsky
May 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ira M JacobsonJean-Pierre Bronowicki
Jun 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick MarcellinMario Rizzetto
Oct 30, 2012·Journal of Hepatology·Christian M Lange, Stefan Zeuzem
Dec 18, 2013·Journal of Hepatology·UNKNOWN European Association for Study of Liver

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BETA
Assay

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PASW statistic

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