The Usefulness of Genotyping of Celiac Disease-Specific HLA among Children with Type 1 Diabetes in Various Clinical Situations

Journal of Diabetes Research
Grazyna DejaPrzemysława Jarosz-Chobot

Abstract

The aim of the study was to determine the usefulness of HLA DQ2/DQ8 genotyping in children with T1D in various clinical situations: as a screening test at the diabetes onset, as a verification of the diagnosis in doubtful situations, and as a test estimating the risk of CD in the future. Materials and methods. Three groups of patients with T1D were included: newly diagnosed (n = 92), with CD and villous atrophy (n = 92), with CD and villous atrophy (n = 92), with CD and villous atrophy (. The results of genetic tests confirmed the presence of DQ2/DQ8 in 94% of children with diabetes (group I) and in 100% of children with diabetes and CD (groups II and III, respectively). Comparative analysis of the HLA DQ2/DQ8 distribution did not show any differences. Allele DRB1∗04 (linked with HLA DQ8) was significantly less common in children with diabetes and CD (group I versus groups II and III, 56.5% vs. 24.5%; p = 0.001). The probability of developing CD in DRB1∗04-positive patients was 4 times lower (OR 0.25; 95% CI 0.118-0.529; p = 0.001). The probability of developing CD in DRB1∗04-positive patients was 4 times lower (OR 0.25; 95% CI 0.118-0.529; p = 0.001). The probability of developing CD in DRB1∗04-positive patients was 4 times lo...Continue Reading

References

May 27, 2004·Diabetes Care·Franco CeruttiUNKNOWN Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology
Mar 1, 2008·Gastrointestinal Endoscopy·Wilson P PaisCharles N Bernstein
Oct 8, 2009·The American Journal of Gastroenterology·Dascha C WeirAlan M Leichtner
Nov 6, 2010·The Journal of Pediatrics·Elke E Fröhlich-ReitererUNKNOWN Diabetes Patienten Verlaufsdokumentationssystem-Wiss Study Group
Jul 16, 2011·PloS One·Maria Pia SperandeoLuigi Greco
Aug 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Beate SkinningsrudDag E Undlien
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·S HusbyUNKNOWN European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
Jun 8, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·A Pham-ShortM E Craig
Nov 17, 2012·World Journal of Gastroenterology : WJG·Naiyana GujralAlan B R Thomson
Jun 21, 2013·Alimentary Pharmacology & Therapeutics·J Y KangK Y Ho
Apr 30, 2014·The American Journal of Gastroenterology·Renata AuricchioLuigi Greco
Oct 2, 2014·Alimentary Pharmacology & Therapeutics·P ElfströmJ F Ludvigsson
Oct 28, 2015·Nutrients·Rachele CiccocioppoLuis Rodrigo
Mar 4, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·A ChobotP Jarosz-Chobot

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
biopsies
biopsy
PCR
ELISA

Software Mentioned

Statistica
ESPGHAN
ESPHGAN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Internal Medicine
Luca ElliDetlef Schuppan
Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology
Miren Vicuña ArreguiMercedes Palacios Sarrasqueta
Journal of Pediatric Gastroenterology and Nutrition
Norelle R ReillyPeter H R Green
© 2021 Meta ULC. All rights reserved