The usefulness of hCG and unconjugated oestriol in prenatal diagnosis of trisomy 18

British Journal of Obstetrics and Gynaecology
N LeporrierP Leymarie

Abstract

To evaluate the usefulness of the two maternal serum markers, human chorionic gonadotrophin (hCG) and unconjugated oestriol (uE3), in the prenatal diagnosis of trisomy 18. Retrospective evaluation of uE3 and hCG levels at mid-trimester in cases ot trisomy 18 pregnancies identified from a series of women screened for Down's syndrome. From a series of 53,893 women screened in the antenatal centre of University Hospital of Caen (France), 22 cases of trisomy 18 were diagnosed either after amniocentesis for maternal age, elevated risk of Down's syndrome, or fetal abnormalities and/or growth retardation on ultrasound assessment, or after birth. In addition, ll cases of trisomy 18 identified prenatally in two other centres were included. Individual hCG and uE3 levels for pregnancies with trisomy 18 were significantly lower than in unaffected pregnancies: mean hCG was 0.62 multiples of the median (MoM) and median hCG was 0.5 MoM. uE3 was a much more effective marker than hCG. Mean uE3 was 0.40 MoM and median uE3 was 0.37 MoM. It was observed that screening for trisomy 18 based on selection for amniocentesis with cut-off values of 0.55 for hCG and 0.60 for uE3 would lead to a detection rate of 48% for 0.8% false positive rate. Using cut...Continue Reading

References

Oct 24, 1992·BMJ : British Medical Journal·N LeporrierP Leymarie
Jan 1, 1990·Clinical Genetics·B Nørgaard-PedersenA Tabor
Aug 1, 1990·Prenatal Diagnosis·J A CanickR Osathanondh
Sep 1, 1987·Prenatal Diagnosis·R H LindenbaumJ Keenan
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Apr 1, 1984·American Journal of Obstetrics and Gynecology·I R MerkatzW E Johnson
Dec 4, 1993·BMJ : British Medical Journal·K SpencerJ N Macri
Aug 1, 1994·Prenatal Diagnosis·S WalkinshawA Spriggs
Feb 12, 1994·BMJ : British Medical Journal·T Davies

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Citations

Dec 18, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·C GeylV Debarge
Aug 15, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R SharonyM Fejgin

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