The Utility of 12-Hour Urine Collection for the Diagnosis of Preeclampsia: A Systematic Review and Meta-analysis

Obstetrics and Gynecology
Molly J StoutMethodius G Tuuli

Abstract

To systematically review the literature and synthesize data on the diagnostic performance of a 12-hour urine collection for proteinuria in pregnant women with suspected preeclampsia. We performed a literature search of PubMed, Embase, Scopus, ClinicalTrials.gov, and CINAHL through February 2014 using key words related to gestational hypertension, preeclampsia, and proteinuria. Studies that contained results of both the 12-hour and 24-hour urine collection in the same patients were eligible. Three independent reviewers abstracted test performance characteristics from each study for the performance of a 12-hour urine collection for the diagnosis of proteinuria defined as 300 mg in 24 hours. Diagnostic meta-analysis was performed to obtain summary statistics. Heterogeneity was assessed using the Cochrane Q or I. Receiver operating characteristic curve analysis was used to assess the optimal diagnostic cutpoint for proteinuria from a 12-hour urine collection. Stratified analysis was performed based on whether patients were on bed rest during urine collection. A total of seven studies met inclusion criteria. The 12-hour urine protein was overall highly predictive of proteinuria on 24-hour urine collection area under receiver operati...Continue Reading

References

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Citations

Mar 22, 2018·F1000Research·Kate DuhigAndrew Shennan
Jan 25, 2017·Autism Research and Treatment·Patricia O Towle, Patricia A Patrick
May 26, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rita M SilvaNuno Clode
Sep 4, 2020·American Journal of Obstetrics and Gynecology·Michal Fishel BartalBaha M Sibai

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