The utility of 82 Rb PET for myocardial viability assessment: Comparison with perfusion-metabolism 82 Rb-18 F-FDG PET

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Jonathan B MoodyEdward P Ficaro

Abstract

82Rb kinetics may distinguish scar from viable but dysfunctional (hibernating) myocardium. We sought to define the relationship between 82Rb kinetics and myocardial viability compared with conventional 82Rb and 18F-fluorodeoxyglucose (FDG) perfusion-metabolism PET imaging. Consecutive patients (N = 120) referred for evaluation of myocardial viability prior to revascularization and normal volunteers (N = 37) were reviewed. Dynamic 82Rb 3D PET data were acquired at rest. 18F-FDG 3D PET data were acquired after metabolic preparation using a standardized hyperinsulinemic-euglycemic clamp. 82Rb kinetic parameters K1, k2, and partition coefficient (KP) were estimated by compartmental modeling RESULTS: Segmental 82Rb k2 and KP differed significantly between scarred and hibernating segments identified by Rb-FDG perfusion-metabolism (k2, 0.42 ± 0.25 vs. 0.22 ± 0.09 min-1; P < .0001; KP, 1.33 ± 0.62 vs. 2.25 ± 0.98 ml/g; P < .0001). As compared to Rb-FDG analysis, segmental Rb KP had a c-index, sensitivity and specificity of 0.809, 76% and 84%, respectively, for distinguishing hibernating and scarred segments. Segmental k2 performed similarly, but with lower specificity (75%, P < .001) CONCLUSIONS: In this pilot study, 82Rb kinetic param...Continue Reading

References

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Aug 7, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Edward P FicaroJames R Corbett
Apr 14, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinRobert A deKemp
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Jun 19, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kevin C Allman
Oct 13, 2014·JACC. Cardiovascular Imaging·Sergey V NesterovJuhani M Knuuti
Apr 15, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jonathan B MoodyVenkatesh L Murthy
May 15, 2015·IEEE Transactions on Medical Imaging·Jonathan B MoodyEdward P Ficaro
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Aug 20, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jennifer M RenaudRobert A deKemp

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Citations

May 16, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael A AlJaroudi, Fadi G Hage
Nov 7, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jonathan B MoodyVenkatesh L Murthy
Mar 22, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dominik C BenzRonny R Buechel
Feb 16, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Feifei ZhangYuetao Wang
May 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jennifer K Lang, John M Canty
Feb 28, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Karthik Ananthasubramaniam, Parthiban Arumugam
Oct 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Piotr J SlomkaErnest V Garcia
Oct 18, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Piotr J SlomkaErnest V Garcia
May 11, 2021·Clinical Physiology and Functional Imaging·Wail NammasAntti Saraste
Nov 28, 2021·International Journal of Molecular Sciences·Tomasz Jan KolanowskiMaciej Kurpisz

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