The utility of a somatostatin-type receptor binding peptide radiopharmaceutical (P829) in the evaluation of solitary pulmonary nodules

Chest
J BlumN Rinne

Abstract

Many neoplasms including small cell cancers more densely express somatostatin-type receptors or more avidly bind somatostatin than granulomatous and other nonmalignant processes. While non-small cell neoplasms of the lung have not yet been shown to demonstrate this receptor expression, previous studies have documented non-small cell lung cancer detection with somatostatin analog scintigraphy. This phenomenon can be conceivably exploited utilizing technetium Tc-99m P829 (P829), a unique low molecular weight somatostatin-type receptor binding polypeptide radiopharmaceutical. The objective of this study was to determine the ability of P829 scintigraphy to noninvasively differentiate malignant and nonmalignant solitary pulmonary nodules (SPNs). The radiopharmaceutical technetium 99mTc-P829 was utilized for scintigraphy including single photon emission computed tomography. Thirty individuals with indeterminate SPNs of > or = 1 cm and significant risk factors for primary lung cancer were identified and underwent P829 scintigraphy. Tissue diagnosis was then established by transthoracic needle biopsy specimens. Fourteen subjects demonstrated abnormal P829 scans in the region of the radiographic abnormality. Twelve of this group had bio...Continue Reading

References

Aug 1, 1976·Journal of Medicinal Chemistry·J E RivierW W Vale
Apr 1, 1990·AJR. American Journal of Roentgenology·W R Webb
Aug 1, 1986·Radiology·S S SiegelmanE A Zerhouni
Aug 1, 1986·Radiology·E A ZerhouniR T Heelan
Sep 28, 1970·JAMA : the Journal of the American Medical Association·E L WynderE J Beattie
Oct 1, 1994·European Journal of Nuclear Medicine·D J KwekkeboomE P Krenning
Dec 1, 1993·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K J O'Byrne, D N Carney
Jan 25, 1996·The New England Journal of Medicine·S W LambertsL J Hofland
May 1, 1996·Cancer·W A FryD P Winchester
Jan 1, 1996·Anti-cancer Drugs·K J O'Byrne, D N Carney

❮ Previous
Next ❯

Citations

Sep 14, 2004·Annals of Nuclear Medicine·Donald J BuchsbaumKurt R Zinn
May 7, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Arnaud HalleyDenis Agostini
Jul 13, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Martin GotthardtThomas M Behr
Mar 12, 2004·The Journal of Surgical Research·Alan D L Sihoe, Anthony P C Yim
Nov 16, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ronald E Weiner, Mathew L Thakur
Apr 11, 2001·Nuclear Medicine and Biology·K R ZinnB E Rogers
Nov 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Georg Riccabona, Clemens Decristoforo
Jun 10, 2004·Cancer Biotherapy & Radiopharmaceuticals·Teresa MartinsLuis Oliveira
Jun 10, 2004·Cancer Biotherapy & Radiopharmaceuticals·Anna PlachcinskaJacek Kusmierek
Jan 25, 2005·Cancer Biotherapy & Radiopharmaceuticals·Bieke Van Den BosscheChristophe Van de Wiele
Oct 12, 2001·Clinical Nuclear Medicine·R S Morehead, W J Shih
Jun 5, 2002·Clinical Nuclear Medicine·John S Miliziano, Yong C Bradley
Dec 18, 2004·Clinical Nuclear Medicine·Zairong GaoJan Bucerius
May 20, 2006·Nuclear Medicine Communications·Nuria FerranJose Martin-Comin
Jul 27, 2000·Current Opinion in Pulmonary Medicine·D E Midthun
Sep 7, 2013·Medical Physics·Howard C Gifford
Jul 21, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J E Blum, H Handmaker
Dec 14, 2007·Journal of Endocrinological Investigation·P AmeriD Ferone
Apr 18, 2003·Journal of Thoracic Imaging·Linda P ThomasMatthew D Gilman
Jan 16, 2003·Chest·Gerard A SilvestriUNKNOWN American College of Chest Physicians
Nov 5, 2003·Clinical Lung Cancer·Martin GotthardtThomas M Behr
Jan 14, 2003·Seminars in Nuclear Medicine·Josef MachacChun Kim
Nov 17, 2001·Seminars in Nuclear Medicine·R E Weiner, M L Thakur
Nov 9, 2004·Archivos de bronconeumología·A C RebolloJ L Velasco
Aug 6, 2000·Seminars in Nuclear Medicine·O C BoermanF H Corstens
Jun 16, 2000·Radiologic Clinics of North America·S J Goldsmith, L Kostakoglu
Apr 18, 2003·Chest Surgery Clinics of North America·Rosaleen B ParsonsLee P Adler
Sep 24, 2004·Thoracic Surgery Clinics·Stanley J GoldsmithChristopher J Palestro
Apr 20, 2002·Seminars in Nuclear Medicine·Yusuf Menda, Daniel Kahn
Apr 20, 2002·Seminars in Nuclear Medicine·Richard R P Warner, Thomas M O'dorisio
May 25, 2012·TheScientificWorldJournal·Varvara ValotassiouPanagiotis Georgoulias
Jan 1, 2011·Journal of lung cancer·J Clay CallisonPierre P Massion

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.