The utility of breast cone-beam computed tomography, ultrasound, and digital mammography for detecting malignant breast tumors: A prospective study with 212 patients

European Journal of Radiology
Ni HeWei-Dong Wei

Abstract

Breast cone-beam computed tomography (BCBCT) is a flat-panel detector (FPD)-based X-ray imaging system that provides high-quality images of the breast. The purpose of this study was to investigate the ability to detect breast abnormalities using non-contrast BCBCT and contrast-enhanced BCBCT (BCBCT and CE-BCBCT) compared to ultrasound (US) and digital mammography (MG). A prospective study was performed from May 2012 to August 2014. Ninety-two patients (172 lesions) underwent BCBCT alone, and 120 patients (270 lesions) underwent BCBCT and CE-BCBCT, all the patients underwent US and MG. Cancer diagnosis was confirmed pathologically in 102 patients (110 lesions). BCBCT identified 97 of 110 malignant lesions, whereas 93 malignant lesions were identified using MG and US. The areas under the receiver operating curves (AUCs) for breast cancer diagnosis were 0.861 (BCBCT), 0.856 (US), and 0.829 (MG). CE-BCBCT improved cancer diagnostic sensitivity by 20.3% (78.4-98.7%). The AUC values were 0.869 (CE-BCBCT), 0.846 (BCBCT), 0.834 (US), and 0.782 (MG). In this preliminary study, BCBCT was found to accurately identify malignant breast lesions in a diagnostic setting. CE-BCBCT provided additional information and improved cancer diagnosis in...Continue Reading

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Citations

Nov 13, 2018·Physics in Medicine and Biology·Marco CaballoIoannis Sechopoulos
Jul 6, 2017·European Radiology·Susanne WienbeckUwe Fischer
Jul 10, 2019·Journal of Surgical Oncology·Tiffany C LeeJaime D Lewis
Jan 25, 2020·European Radiology·Seyedamir Tavakoli TabaPatrick C Brennan
Jan 11, 2018·Seminars in Ultrasound, CT, and MR·Avice M O'ConnellDaniel T Kawakyu-O'Connor
Nov 7, 2017·Ultrasound in Medicine & Biology·Rongrong GuoBaowei Fei

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