The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis

The American Journal of Gastroenterology
A H PatelGregory J Gores


The diagnosis of cholangiocarcinoma is often difficult, making management approaches problematic. A reliable serum tumor marker for cholangiocarcinoma would be a useful additional diagnostic test. Previous studies have demonstrated that elevated serum concentrations of CA 19-9, a tumor-associated antigen, have good sensitivity and specificity for cholangiocarcinoma in patients with primary sclerosing cholangitis. However, the value of this tumor marker for cholangiocarcinoma unassociated with primary sclerosing cholangitis is unclear. Thus, the aims of this study were to determine the usefulness of a serum CA 19-9 determination in the diagnosis of de novo cholangiocarcinoma. We prospectively measured serum CA 19-9 concentrations in patients with cholangiocarcinoma (n = 36), nonmalignant liver disease (n = 41), and benign bile duct strictures (n = 26). Serum CA 19-9 concentrations were measured by an immunoradiometric assay (CIS Bio International) without knowledge of the clinical diagnosis. The sensitivity of a CA 19-9 value >100 U/ml in diagnosing cholangiocarcinoma was 53%. When compared with the nonmalignant liver disease and the benign bile duct stricture groups, the true negative rates were 76% and 92%, respectively. Patie...Continue Reading


Oct 1, 1988·Digestive Diseases and Sciences·M B AlbertJ P Henry
Mar 1, 1985·Investigative Radiology·R H CohanN R Dunnick
Mar 15, 1984·International Journal of Cancer. Journal International Du Cancer·R E RittsV R Zurawski
Dec 1, 1981·AJR. American Journal of Roentgenology·G S HarellP F Berry
Mar 1, 1994·Gastrointestinal Endoscopy·A P Ferrari JúniorD L Carr-Locke

❮ Previous
Next ❯


Feb 16, 2008·Journal of Hepato-biliary-pancreatic Surgery·Shuichi MiyakawaUNKNOWN Japan Society of Clinical Oncology
Feb 16, 2008·Journal of Hepato-biliary-pancreatic Surgery·Kazuhiro TsukadaUNKNOWN Japan Society of Clinical Oncology
Jul 23, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yuan ShiChenghong Peng
Oct 9, 2008·Journal of Proteome Research·Troels Zakarias KristiansenAkhilesh Pandey
Aug 3, 2011·Nature Reviews. Gastroenterology & Hepatology·Boris BlechaczGregory J Gores
Nov 14, 2007·Gut·S A KhanS D Taylor-Robinson
Oct 12, 2002·Gut·S A KhanUNKNOWN British Society of Gastroenterology
May 2, 2009·BMC Gastroenterology·Kawin LeelawatJerasak Wannaprasert
Dec 5, 2012·BMC Clinical Pathology·Sayo KawaiNobuyuki Hamajima
Jul 19, 2008·World Journal of Gastroenterology : WJG·Andreas WeberChristian Prinz
Jul 19, 2008·World Journal of Gastroenterology : WJG·Anastassios-C ManolakisSpyros-P Potamianos
Nov 26, 2008·World Journal of Gastroenterology : WJG·Yucel Ustundag, Yusuf Bayraktar
Sep 15, 2009·World Journal of Gastroenterology : WJG·Murad AljiffryMichele Molinari
Sep 28, 2010·World Journal of Gastroenterology : WJG·Kawin LeelawatThawee Ratanashu-ek
Apr 2, 2011·World Journal of Gastroenterology : WJG·Hua-Bang ZhouHe-Ping Hu
Aug 25, 2012·World Journal of Gastroenterology : WJG·Gaetano La GrecaDomenico Russello
Nov 6, 2015·Journal of Gastrointestinal Cancer·Ufuk Barış KuzuErtuğrul Kayaçetin
Mar 17, 2007·Cancer Investigation·Nikolaos K GatselisGeorgios N Dalekos
Apr 25, 2006·Alimentary Pharmacology & Therapeutics·H Malhi, G J Gores
May 19, 2011·Expert Opinion on Pharmacotherapy·Constantin A DasanuGuru Trikudanathan
May 27, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Grunnet, M Mau-Sørensen
Jan 23, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Tiffany Priyanthi HennedigeSudhakar Kundapur Venkatesh
May 28, 2016·Biomarkers in Medicine·Bin WangHao-Teng Chang
Sep 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiongbo WuFangmei An
Dec 9, 2016·Gut and Liver·Boris Blechacz
Jul 2, 2014·The American Journal of Tropical Medicine and Hygiene·Hee Jung YoonBounlay Phommasack
Mar 25, 2009·Surgical Oncology Clinics of North America·Cherif BoutrosN Joseph Espat
Mar 18, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sundeep Singh SalujaTushar Kanti Chattopadhyay
Aug 18, 2009·Photodiagnosis and Photodynamic Therapy·Ron R AllisonClaudio H Sibata
Apr 16, 2004·Molecular & Cellular Proteomics : MCP·Troels Zakarias KristiansenAkhilesh Pandey
Dec 25, 2013·The Journal of International Medical Research·Denghua YaoXiao Li
Jun 1, 2017·Proteomics. Clinical Applications·Lucy BeteshAnand Mehta
Dec 16, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ahmad Hassan AliKeith D Lindor
Jan 6, 2005·World Journal of Gastroenterology : WJG·Apa JuntaveeSopit Wongkham
May 22, 2018·Expert Review of Gastroenterology & Hepatology·Seyed Alireza TaghaviKamran Bagheri Lankarani
Jun 8, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David GoldenbergAnirban Maitra
Apr 12, 2018·The American Journal of Tropical Medicine and Hygiene·Gyem TsheringKesara Na-Bangchang
May 29, 2018·Digestive Diseases·Sven H LoosenTom Luedde
Dec 10, 2013·Clinical Journal of Gastroenterology·Yohei OtaItaru Endo

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.