The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: an immunohistochemical study of 109 cases

Human Pathology
Hany OsmanMuhammad T Idrees

Abstract

We identified 109 testicular tumors, including pure and mixed germ cell tumors and sex cord-stromal tumors, and conducted immunohistochemical staining for CDX2, DOG1, and GATA3 to address the potential utility of these readily available and commonly used markers in the evaluation of testicular tumors. Their expression has not been previously thoroughly examined in testicular germ cell tumors. The distribution, percentage, and intensity of positivity were assessed. CDX2 was positive in all yolk sac tumors, 25% of choriocarcinomas, 9% of seminomas, and 4% of embryonal carcinomas (sensitivity for yolk sac tumor, 100%; specificity, 89% [teratomas excluded]). CDX2 also stained glandular components within teratomas and identified inconspicuous yolk sac tumor components in 3 cases previously diagnosed as pure embryonal carcinoma. GATA3 was positive in all choriocarcinomas (sensitivity, 100%). Weak GATA3 immunostaining was also seen in 12% of yolk sac tumors and 2 of 2 primitive neuroectodermal tumors. DOG1 was negative in all tumors, but stained spermatocytes and spermatids and the luminal borders of the epididymis and rete testis of nonneoplastic testis. We conclude that CDX2 is a sensitive and relatively specific marker for yolk sac...Continue Reading

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Citations

Oct 7, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I AchourA Ghorbel
Aug 30, 2016·Human Pathology·Liang ChengLawrence M Roth
Oct 21, 2016·Journal of Cutaneous Pathology·Keisuke Goto
Jan 1, 2016·The Journal of International Medical Research·Fatma Oz AtalayHakan Vuruskan
Sep 20, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Annikka WeissferdtCesar A Moran
May 17, 2019·The American Journal of Surgical Pathology·Hari P DhakalChristopher G Przybycin
Aug 7, 2019·Archives of Pathology & Laboratory Medicine·Si Kei, Oyedele A Adeyi

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