The utility of chloroquine in cancer therapy

Current Medical Research and Opinion
Yuan ZhangHong-tao Xiao

Abstract

The anti-malarial drug chloroquine has recently been discovered as a novel anti-tumor agent. This article is to review the recent development of chloroquine being used in cancer therapy. PubMed, ScienceDirect and ClinicalKey served as the major databases. Key words included 'chloroquine', 'cancer', and 'autophagy'. The publication date was up to June 2015. Chloroquine mainly executes its anti-tumor function through inhibition of autophagy. It can accumulate inside the lysosome resulting in lysosomal membrane permeabilization (LMP) which will eventually lead to apoptosis. Chloroquine has been shown to stabilize p53 and induce p53-dependent apoptosis or cell cycle arrest. It can also inhibit ABC (ATP-binding cassette) family protein. The anti-cancer effect of chloroquine has been observed both in vitro and in vivo. However, it is considered more as a potential chemotherapy and radiotherapy sensitizer rather than an antineoplastic. Although the utility of chloroquine is promising in cancer therapy, some safety issues have been brought to attention, and further studies on safety profile and the signs of clinical activity of chloroquine including its derivatives should be conducted.

References

Jan 7, 1972·Nature·C A HomewoodV C Baggaley
Aug 1, 1981·Annals of Tropical Medicine and Parasitology·B AronssonM Wahlgren
Mar 29, 2000·Biochemical Pharmacology·M Vezmar, E Georges
Feb 1, 2003·The Journal of Biological Chemistry·Heiko DüssmannJochen H M Prehn
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Apr 13, 2004·Oncogene·Maria Eugenia GuicciardiGregory J Gores
Oct 4, 2005·The Journal of Clinical Investigation·Beth Levine, Junying Yuan
Jan 18, 2006·Bioorganic & Medicinal Chemistry·Chuandong FanJunying Miao
Jul 4, 2006·The Lancet Oncology·Ashish RustogiRakesh Jalali
Aug 10, 2007·Nature·Curtis R Chong, David J Sullivan
Jul 23, 2008·Molecular and Cellular Biology·Urmi BandyopadhyayAna Maria Cuervo
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Oct 10, 2009·The American Journal of Pathology·Shin-ichiro HayashiShigeru Nakashima
Oct 20, 2009·European Journal of Pharmacology·V Raja Solomon, Hoyun Lee
Nov 10, 2009·Nature Cell Biology·Mitsuko Hayashi-NishinoAkitsugu Yamamoto
Jun 22, 2010·European Journal of Medicinal Chemistry·V R SolomonHoyun Lee
Aug 18, 2010·Antioxidants & Redox Signaling·Eugenia MorselliGuido Kroemer
Apr 19, 2011·Genes & Development·Akito TakamuraNoboru Mizushima
Apr 29, 2011·Acta Biochimica Et Biophysica Sinica·Chong WangWei-Guo Zhu
May 19, 2011·Nature Reviews. Clinical Oncology·Filip JankuRazelle Kurzrock
Apr 3, 2012·Experimental Cell Research·Maruša Hafner ČesenBoris Turk
Sep 15, 2012·Journal of Ovarian Research·Claudia PeracchioCiro Isidoro
Sep 15, 2012·Annals of the Rheumatic Diseases·Neng-Yu LinJörg H W Distler
Jan 5, 2013·Cancer Research·Tomonori KimuraYoshitaka Isaka
Apr 12, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yiyu ZouBilal Piperdi
May 28, 2013·The Journal of Surgical Research·Michael E EggerLacey R McNally
Dec 10, 2013·Cell·Jessie Yanxiang GuoEileen White
Feb 8, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daisuke HashimotoJohanna Laukkarinen

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Citations

Jan 31, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cheng WangHan-Ming Shen
Jan 31, 2017·Canadian Journal of Physiology and Pharmacology·Changyu DingJiang Zheng
Apr 14, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Boscolli Barbosa Pereira
Sep 17, 2020·Journal of Cellular and Molecular Medicine·Md Abdul Alim Al-Bari
Oct 25, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qian LiYong Song
Apr 24, 2017·The Kaohsiung Journal of Medical Sciences·Yi-Chia LinThomas I-Sheng Hwang
Aug 2, 2017·Oxidative Medicine and Cellular Longevity·Rebecca F DielschneiderSpencer B Gibson
May 4, 2021·Digestive Diseases and Sciences·Fatma El Zahraa MohamedRajai Munir Al-Jehani
Jul 9, 2021·Apoptosis : an International Journal on Programmed Cell Death·Xiaofeng DaiJianying Zhang

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