The utility of diffusion chambers as models for the description of drug disposition

The Journal of Antimicrobial Chemotherapy
U GanzingerG Gumhold

Abstract

Tissue cages were employed to explore the diffusion processes of several cephalosporins into extravascular fluids. Concentrations of cefotaxime in serum and in subcutaneous chambers increased proportionally to the amount of the drug injected. Administration of single equal doses of cephalothin, cephaloridine and cefotaxime resulted in different concentration-time courses in the serum and in diffusion chambers. These observations suggest that diffusion chambers are linked to the tissue at the implantation site. None of the classical compartmental approaches can be applied to evaluate the kinetics of drug diffusion into tissue cages. Correlations of total or non-protein bound drug concentrations in tissue cages to those in the peripheral compartment assumed concentration and time dependent diffusion processes. No specific diffusion constant based on the law of Fick could be derived for the diffusion chambers used in this study. Concentration-time courses in serum and interstitial fluid can be simultaneously evaluated according to pharmacokinetic-pharmacodynamic models. Based on the equation describing the effect site this model can be used to simulate drug concentrations in tissue cages by varying the dose size or the dose interval.

Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·U Ganzinger, K Neumann
Jan 17, 2009·The Journal of Antimicrobial Chemotherapy·Nobumasa AokiKeizo Yamaguchi
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau
Feb 28, 1991·The New England Journal of Medicine·G A Jacoby, G L Archer
Feb 26, 2013·Journal of Chemotherapy·Dominique BreilhEmmanuel Boselli

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