The Utility of GATA3 in the Diagnosis of Urothelial Carcinomas With Variant Morphologic Patterns

Applied Immunohistochemistry & Molecular Morphology : AIMM
Lindsey VerduinMark R Wick

Abstract

The transcription factor GATA3 is a recently described biomarker that is highly expressed in bladder and breast carcinomas. Although it has shown sensitivity as a marker of primary bladder carcinomas with purely urothelial differentiation, the ability of GATA3 to label primary bladder carcinomas with variant morphologic patterns has been incompletely assessed to date. The current study was designed to determine whether GATA3 staining is retained in "unconventional" bladder carcinomas. Eighty-eight cases of primary bladder cancers were retrieved from the authors' institutional archive, and they included the following histomorphologic types: 6 small cell carcinomas, 12 sarcomatoid carcinomas, 17 adenocarcinomas (both primary and urothelial variants with glandular differentiation), 24 micropapillary carcinomas, and 27 squamous cell carcinomas (both primary and urothelial variants with squamous differentiation). A tissue microarray was constructed and automated immunostaining for GATA3 (Clone L50-823, Biocare Medical, Concord, CA) was performed using standard technique. Among the 5 variants of unconventional bladder carcinoma, only the micropapillary and sarcomatoid forms exhibited consistent and strong immunolabeling for GATA3. He...Continue Reading

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Citations

Feb 27, 2020·Archives of Pathology & Laboratory Medicine·Jenny RossXiming J Yang
Feb 6, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Suvradeep MitraArup K Mandal
Nov 11, 2020·Reviews in Endocrine & Metabolic Disorders·Stefano La Rosa, Silvia Uccella

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