The utility of gingival crevicular fluid matrix metalloproteinase-8 response patterns in prediction of site-level clinical treatment outcome

Journal of Periodontology
Jussi M LeppilahtiPaivi Mantyla

Abstract

Different gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-8 response patterns were studied among non-smoking and smoking patients with chronic periodontitis (CP) and generalized aggressive periodontitis (GAgP) to test the utility of GCF MMP-8 levels predicting the site-level treatment outcome. Data from four independent longitudinal studies were combined. Altogether, the studies included 158 periodontal sites from 67 patients with CP and 32 patients with GAgP, and GCF samples were collected at baseline, after the treatment, and during the 6-month maintenance period. All GCF samples were analyzed by immunofluorometric assay for MMP-8. Different site-level MMP-8 response patterns were explored by the cluster analysis. Most optimal MMP-8 cutoff levels were searched with receiver operating characteristic analyses, and the predictive utility of defined levels was tested. Distinct types of MMP-8 response patterns were found in both smokers and non-smokers. MMP-8 levels exceeding the optimal cutoff levels separately defined for smokers and non-smokers indicated increased risk for compromised treatment outcome at baseline and during the maintenance period. Seventy-one percent of non-smokers (positive likelihood ratio of ...Continue Reading

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Citations

Sep 25, 2016·Journal of Periodontal Research·M T C Mc CruddenF T Lundy
Jan 25, 2017·Diagnostics·Nilminie RathnayakeTimo Sorsa
Jul 4, 2017·Journal of Periodontology·Sarhang S GulCharles W I Douglas
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Aug 14, 2020·Journal of Periodontal Research·Zeynep Pinar Keles YucelTimo Sorsa
Sep 13, 2017·Journal of Periodontal Research·E F de MoraisR A Freitas
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Mar 21, 2019·Periodontology 2000·Andrea Mombelli
Jan 2, 2021·International Journal of Environmental Research and Public Health·Ji-Youn Kim, Han-Na Kim
May 7, 2021·BMC Oral Health·Maha R TaalabDania M Abdelaziz
Sep 2, 2021·Expert Review of Proteomics·Timo SorsaKrishan Gauba
Nov 21, 2021·Clinical and Experimental Dental Research·Kehinde UmeizudikeTimo Sorsa

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