The utility of magnetic resonance imaging in cardiac tissue regeneration trials

Nature Clinical Practice. Cardiovascular Medicine
Valentin FusterSanjay Rajagopalan

Abstract

The past decade has seen the emergence of paradigm shifts in concepts involving cardiovascular tissue regeneration, including the idea that adult stem cells originate in hematopoietic or bone marrow cells, the belief that even adult organs, such as the heart and nervous system, are capable of post-mitotic regeneration, and the concept of inherent plasticity in cells that have undergone limited lineage differentiation. There has consequently been a flurry of proposed regenerative strategies, and safety and limited efficacy data from both animal and limited human trials have been presented. The drive to push these advances from the bench to the bedside has created a unique environment where the therapeutic agents, delivery approaches, and methods of measuring efficacy (often imaging technology) are evolving practically in parallel. The encouraging results of recent cell-therapy trials should therefore be assessed cautiously and in consonance with an understanding of the advantages and limitations of delivery strategies and end points. Arguably, the use of imaging technologies to evaluate surrogate end points might help overcome the difficulty posed by large sample sizes required for hard end point trials in cardiovascular therape...Continue Reading

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Citations

Jun 2, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S A J ChamuleauR Bolli
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Dec 17, 2011·JACC. Cardiovascular Imaging·Karl H SchuleriAlbert C Lardo
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Valentin Fuster, Javier Sanz
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Pedro L SánchezFrancisco Fernández-Avilés
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Robert W GraussDouwe E Atsma
Feb 28, 2007·Contrast Media & Molecular Imaging·Alexis JacquierMaythem Saeed

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