The utility of metaiodobenzylguanidine (MIBG) scintigraphy in patients with pheochromocytoma

Annals of Surgical Oncology
David Yü GreenblattHerbert Chen

Abstract

Radiolabeled metaiodobenzylguanidine scintigraphy (MIBG) can be used to image pheochromocytomas. While cross-sectional imaging techniques such as computed tomography (CT) or magnetic resonance imaging (MRI) usually localize the tumor, MIBG is often obtained to rule out multifocal and metastatic disease, and to corroborate anatomic imaging with functional data. We questioned the utility of MIBG in the diagnosis and management of pheochromocytoma. All patients who received MIBG at one academic center from 1999 to 2004 were identified. For the subset of patients who received MIBG in the work-up of possible pheochromocytoma, the following data were reviewed: demographics, symptoms, results of biochemical and imaging studies, histopathological diagnosis, and management. A total of 60 patients received MIBG, including 27 patients for the evaluation of a possible pheochromocytoma. Biochemical testing was performed in all patients. Fourteen patients received MIBG despite normal biochemistry and an absence of risk factors such as a hereditary syndrome or prior history of pheochromocytoma. None of these 14 low-risk patients with negative biochemistry had a final diagnosis of pheochromocytoma. In the ten patients with pheochromocytoma, al...Continue Reading

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Citations

Sep 24, 2014·Surgical Oncology Clinics of North America·Julie H Song, William W Mayo-Smith
Dec 21, 2010·Seminars in Oncology·Jorge A Carrasquillo, Clara C Chen
Sep 1, 2015·Radiologic Clinics of North America·Brian C Allen, Isaac R Francis
Jun 11, 2009·Clinical Endocrinology·Bas HavekesKarel Pacak
Apr 6, 2012·Seminars in Nuclear Medicine·James C Sisson, Gregory A Yanik
Nov 28, 2015·Surgical Oncology Clinics of North America·Colleen M Kiernan, Carmen C Solórzano
Feb 27, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M D GrossD Rubello
Apr 14, 2016·AJR. American Journal of Roentgenology·Robert W GarrettStewart G Albert
Oct 22, 2008·Clinical Nuclear Medicine·Kim Francis Andersen, Lotte Hahn Enevoldsen
Jan 24, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Christian A Koch
Mar 11, 2010·The Journal of Clinical Endocrinology and Metabolism·S G WaguespackC Jimenez
Jan 12, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Irina LevRun Yu
Jan 28, 2017·Indian Journal of Surgical Oncology·Hattangadi Sanjay Bhat, Balagopal Nair Tiyadath
Aug 26, 2019·Annales d'endocrinologie·Antoine-Guy LopezFrédéric Ziegler

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