The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

The Journal of Infection
Clark D RussellJ Kenneth Baillie

Abstract

To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers. PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible articles. Studies of diagnosis, severity or outcome were included. PROSPERO systematic review registration CRD42017075032. Forty studies were included, reporting on bacterial and viral infections, malaria, and critical illness due to sepsis. Ten studies reported an association of higher NLR with bacteraemia, supported by meta-analysis of patient-level data (five studies, n = 3320; AUC 0.72, p<0.0001) identifying a cut-off of >12.65. Two studies reported an association with lower LMR and diagnosis of influenza virus infection in patients with respiratory tract infection. Meta-analysis of patient-level data (n = 85; AUC 0.66, p = 0.01) identified a cut-off of ≤2.06. The directionality of associations between NLR and outcomes in heterogeneous cohorts of critically ill adults with sepsis varied. Potential clinical utility was also demonstrated in pneumonia (NLR), pertussis (NLR), urinary tract infection (NLR), diabetic foot infections (NLR) and Crimean Congo Haemorrhagic Fever (PLR). Longitudinal measurement ...Continue Reading

Citations

Jul 14, 2020·International Journal of Laboratory Hematology·Jindan KongJianhong Fu
Jul 21, 2020·Therapeutic Advances in Respiratory Disease·Liang XieShanqun Li
Jan 16, 2021·F1000Research·Mudatsir MudatsirHarapan Harapan
Sep 21, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Pilar Storch-de-GraciaRaquel Jiménez
Jun 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Laura Muñoz-DelgadoPablo Mir
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Methods Mentioned

BETA
PCR
amputation
biopsy

Software Mentioned

GraphPad Prism

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