The utility of PET-based imaging for prostate cancer biochemical recurrence: a systematic review and meta-analysis.

World Journal of Urology
Niranjan J SathianathenBadrinath R Konety

Abstract

Conventional imaging modalities have been poor in characterizing the true extent of disease in men with biochemical recurrence following primary treatment for prostate cancer. Functional imaging with positron emission tomography (PET) has shown promise of being a superior imaging modality. We conducted a systematic review and meta-analysis to define the diagnostic accuracy of PET/CT using 11C-choline, 18F-FACBC, or 68Ga-PSMA in detecting recurrent prostate cancer. We searched multiple databases in line with the preferred reporting items for systematic review and meta-analysis (PRISMA) statement to define the diagnostic accuracy of 11C-choline, 18F-FACBC, or 68Ga-PSMA PET/CT. Only studies secondarily staging participants with biochemical recurrence and those with an appropriate reference standard (pathology, further imaging, and/or clinical response) were eligible for analysis. Twenty-one studies with 3202 participants met the inclusion criteria. Of these, 11C-choline, 18F-FACBC, and 68Ga-PSMA were the tracer investigated in 16, 5, and 1 studies, respectively. The summary sensitivity for each tracer was 80.9% (95% CI 70.4-88.3%), 79.7% (95% CI 51.9-93.4%), and 76.4% (95% CI 68.3-82.9%), respectively. The corresponding summary sp...Continue Reading

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Citations

Dec 24, 2018·European Journal of Clinical Investigation·Ricardo Pereira MestreEnrico Roggero
Feb 23, 2019·World Journal of Urology·Henk van der PoelIvo Schoots
May 30, 2019·World Journal of Urology·D Bolton, M Frydenberg
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Apr 29, 2019·World Journal of Urology·Sanchia Goonewardene
Sep 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kelsey L PomykalaJeremie Calais

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