The utility of rifampin in diagnosing Gilbert's syndrome

The American Journal of Gastroenterology
G D MurthyD Pasquale

Abstract

The aim of this study was to evaluate the effect of rifampin (the "rifampin test") on serum bilirubin in patients with and without Gilbert's syndrome. We conducted a clinical trial in which the effect of rifampin on serum bilirubin level in 15 patients with Gilbert's syndrome was compared with 10 patients without Gilbert's syndrome (controls) in a General Internal Medicine/Primary Care clinic of a Veterans Affairs medical center. Each participant underwent a "rifampin test," i.e., bilirubin measurement at baseline and 2, 4, and 6 h after the administration of 900 mg of rifampin. Measurements included complete blood count, blood chemistry including liver panel tests (ALP, AST, LDH, and albumin) along with total serum bilirubin levels. Ten patients with Gilbert's and nine control patients had haptoglobin level measured at baseline and 6 h after the administration of rifampin. While fasting, the mean rise in total serum bilirubin at 2, 4, and 6 h after the administration of rifampin, respectively, was 0.5, 0.7, and 0.7 mg/dl (analysis of variance, p < 0.001) in control patients and 0.6, 1.0, and 1.1 mg/dl (p < 0.001) in the study patients. In 15 fed subjects (six control and nine study), the mean rise in total serum bilirubin at 2...Continue Reading

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Citations

Aug 20, 2008·BMC Research Notes·Niels TeichIngolf Schiefke
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A Ayrton, P Morgan
May 1, 2012·Alimentary Pharmacology & Therapeutics·M HjelkremS A Harrison
Mar 16, 2011·Annals of Saudi Medicine·Forough SakiMahmoud Haghighat
Dec 14, 2011·European Journal of Pediatrics·Andrew FretzayasThemistocles Karpathios
Nov 9, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Olayinka A AdebayoOluwatosin A Adaramoye

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