The utility of rodent models of autism spectrum disorders

Current Opinion in Neurology
Maria T Lázaro, Peyman Golshani

Abstract

This review discusses the ways that rodent models of autism spectrum disorders (ASDs) have been used to gain critical information about convergent molecular pathways, the mechanisms underlying altered microcircuit structure and function, and as a screen for potential cutting edge-treatments for ASDs. There is convergent evidence that impaired developmental pruning of connections may be a common finding among several mouse models of ASDs. Recent studies have uncovered impaired autophagy by pathological mTOR activation as a potential contributor to microcircuit dysfunction and behavior. ASD-related disinhibition and exaggerated synaptic plasticity in multiple distinct circuits in cortex and reward circuits in striatum also contribute to social dysfunction and repetitive behaviors. New exciting molecular therapeutic techniques have reversed cognitive deficits in models of ASD, indicating that mouse models could be used for preclinical translational studies of new treatments. Rodent models of ASDs coupled to new emerging technologies for genome editing, cell-specific functional and structural imaging, and neuronal activity manipulation will yield critical insights into ASD pathogenesis and fuel the emergence of new treatments.

References

Jan 1, 1994·Lancet·E CourchesneL Schriebman
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kimberly M HuberMark F Bear
Oct 5, 2002·Cellular and Molecular Neurobiology·S Hossein FatemiAmelia Merz
Jun 29, 2004·Trends in Neurosciences·Mark F BearStephen T Warren
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Jun 24, 2008·Nature Medicine·Dan EhningerAlcino J Silva
Dec 27, 2008·Neuron·Dan EhningerAlcino J Silva
Jan 20, 2009·Nature Neuroscience·David K ChowJoshua T Trachtenberg
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing ZhouLuis F Parada
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ali SharmaR Suzanne Zukin
Mar 20, 2010·Biochemical Society Transactions·Stuart CobbAdrian Bird
Jun 19, 2010·Nature Reviews. Neuroscience·Jill L SilvermanJacqueline N Crawley
Apr 17, 2012·Neuron·Aubin MichalonLothar Lindemann
Apr 25, 2012·Brain : a Journal of Neurology·Lianne RobinsonStuart R Cobb
Nov 22, 2012·Nature Methods·Rohit PrakashKarl Deisseroth
Dec 13, 2012·Translational Psychiatry·E LemonnierY Ben-Ari
Dec 20, 2012·Nature Communications·Atsushi SatoMasashi Mizuguchi
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ankur B PatelJay R Gibson
Feb 12, 2013·Nature Neuroscience·Yaniv ZivMark J Schnitzer
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Koichi TakeuchiR Suzanne Zukin
Jun 4, 2013·Nature Neuroscience·J Tiago GonçalvesCarlos Portera-Cailliau
Oct 18, 2013·Nature·Aleksandr ShcheglovitovRicardo E Dolmetsch
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Pablo Garcia-Junco-ClementePeyman Golshani
Nov 1, 2013·Psychopharmacology·Sébastien JacquemontBaltazar Gomez-Mancilla
Nov 2, 2013·Neurologic Clinics·Sunil Q Mehta, Peyman Golshani
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minghui JiangStelios M Smirnakis
Jan 7, 2014·Trends in Neurosciences·Niklas KrummEvan E Eichler
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qionger HeAnis Contractor
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ada C Felix-Ortiz, Kay M Tye
Feb 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ankur B PatelJay R Gibson
Mar 29, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marco PignatelliValeria Bruno
Apr 30, 2014·Communicative & Integrative Biology·Pablo Garcia-Junco-Clemente, Peyman Golshani
Jul 16, 2014·Cell Reports·Luis G RabanedaFrancisco G Scholl

❮ Previous
Next ❯

Citations

May 2, 2016·Human Genetics·Jinting GuanJames J Cai
Feb 16, 2017·Annual Review of Animal Biosciences·Stacey J Sukoff Rizzo, Jacqueline N Crawley
Feb 25, 2018·Psychiatry Investigation·Tamanna Jahan MonyHee Jae Lee
Jan 25, 2018·Scientific Reports·Tomoko HisaokaYoshihiro Morikawa
Feb 15, 2019·Wiley Interdisciplinary Reviews. Cognitive Science·József TopálBorbála Turcsán
Jul 4, 2020·The European Journal of Neuroscience·Murilo S de AbreuAllan V Kalueff
Jul 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Sivan KannerAri Barzilai
Mar 30, 2019·Nature Reviews. Neuroscience·Aaron SathyanesanVittorio Gallo
Jun 3, 2021·International Journal of Environmental Research and Public Health·Judit Biosca-BrullMaria Teresa Colomina
Dec 19, 2021·Cell & Bioscience·Zhiqiang DengZhenyu Yue

❮ Previous
Next ❯

Methods Mentioned

BETA
antisense oligonucleotides

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.