The utility of routine clinical 12-lead ECG in assessing eligibility for subcutaneous implantable cardioverter defibrillator

Computers in Biology and Medicine
Jason A ThomasLarisa G Tereshchenko


The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a life-saving device. Recording of a specialized 3-lead electrocardiogram (ECG) is required for S-ICD eligibility assessment. The goals of this study were: (1) evaluate the effect of ECG filtering on S-ICD eligibility, and (2) simplify S-ICD eligibility assessment by development of an S-ICD ineligibility prediction tool, which utilizes the widely available routine 12-lead ECG. Prospective cross-sectional study participants [n = 68; 54% male; 94% white, with wide ranges of age (18-81 y), body mass index (19-53), QRS duration (66-150 ms), and left ventricular ejection fraction (37-77%)] underwent 12-lead supine, 3-lead supine and standing ECG recording. All 3-lead ECG recordings were assessed using the standard S-ICD pre-implantation ECG morphology screening. Backward, stepwise, logistic regression was used to build a model for 12-lead prediction of S-ICD eligibility. Select electrocardiogram waves and complexes: QRS, R-, S, and T-amplitudes on all 12 leads, averaged QT interval, QRS duration, and R/T ratio in the lead with the largest T wave (R/Tmax) were included as predictors. The effect of ECG filtering on ECG morphology was evaluated. A total of 9 participant...Continue Reading

Associated Clinical Trials

Jul 6, 2017·Larisa Tereshchenko


Oct 13, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Velislav N BatchvarovA John Camm
Aug 30, 2012·The Journal of Emergency Medicine·Richard A HarriganWilliam J Brady
Dec 11, 2013·Journal of Cardiovascular Electrophysiology·Louise R A Olde NordkampReinoud E Knops
Apr 24, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Christopher A GrohBradley P Knight
Jun 1, 2015·International Journal of Cardiology·Louise R A Olde NordkampReinoud E Knops
Sep 13, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Niccolo' MauriziFranco Cecchi
May 12, 2017·HeartRhythm Case Reports·Ankur A KarnikKevin M Monahan
May 16, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R GoldMartin C Burke
May 17, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Pau AlonsoLuis Martinez
Aug 12, 2017·Journal of the American College of Cardiology·Lucas BoersmaUNKNOWN EFFORTLESS Investigator Group

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