The utility of therapeutic drug monitoring for ribavirin in patients with chronic hepatitis C--a critical review

The Annals of Pharmacotherapy
Alice H W ChanMary H H Ensom

Abstract

To evaluate the utility of therapeutic drug monitoring (TDM) for ribavirin in chronic hepatitis C. Literature searches were conducted through PubMed (1949-June 2009), EMBASE (1980-June 2009), BIOSIS Previews (1969-June 2009), International Pharmaceutical Abstracts (1970-June 2009), Google, and www.clinicaltrials.gov using the terms ribavirin, therapeutic monitoring, hepatitis C, and drug levels. In addition, pertinent reference citations from identified publications were reviewed. Studies were limited to English language, adult age, and human subjects. All articles identified from the data sources were evaluated. Studies that measured ribavirin concentrations or dose and treatment response were included in the review. While monitoring of ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C has been described in the literature, the utility of TDM for ribavirin in this group of patients has not been systematically studied. Thus, a previously published 9-step decision-making algorithm was employed to help determine whether TDM is warranted, based on currently available evidence. Thirty articles involving patients with chronic hepatitis C mono-infection, 12 for hepatitis C-HIV coinfecti...Continue Reading

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Citations

Apr 12, 2014·Clinical Pharmacokinetics·Clara T M M de KanterDavid M Burger
Aug 16, 2011·Revista clínica española·M E Valencia, V Moreno
Dec 28, 2010·PharmacoEconomics·George DranitsarisWilliam Evans

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