The UV-derivative spectrophotometry for the determination of doripenem in the presence of its degradation products

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
J Cielecka-Piontek, A Jelińska

Abstract

A spectrophotometric method was developed for the quantitative determination of doripenem in pharmaceutical dosage form (DORIBAX) in the presence of its degradation products. The first-derivative with or without the substration technique, depending on formed products degradation was applied (lambda=324 nm). The method was linear in the range concentration (0.42-11.30)x10(-2)mg L(-1) (r=0.9981), the limits of detection and quantification were 7.60 and 45.0 microg L(-1), respectively. Recovery of doripenem ranged from 99.85 to 102.97% in pharmaceutical dosage form. This method had a good precision (RDS from 0.35 to 2.93%). The observed rate constants for doripenem degradation were comparable to those obtained in recommended HPLC method.

References

Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Hannah M WexlerCalida Li
Mar 30, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Christina Sutherland, David P Nicolau
Feb 7, 2009·Journal of Pharmaceutical and Biomedical Analysis·J Cielecka-PiontekI Oszczapowicz

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Citations

Jun 14, 2013·Chemistry Central Journal·Judyta Cielecka-PiontekPiotr Garbacki
Dec 12, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·J Cielecka-PiontekM Paczkowska
Nov 14, 2013·Pharmaceutical Development and Technology·Judyta Cielecka-PiontekBolesław Barszcz
Jan 31, 2017·Biomedical Chromatography : BMC·Fábio de Souza BarbosaAndreas Sebastian Loureiro Mendez

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