The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CDKAL1, JAZF1, and IGF1 genes

Omics : a Journal of Integrative Biology
Manshu SongWei Wang

Abstract

Substantial evidence suggests that type 2 diabetes mellitus (T2DM) is a multi-factorial disease with a strong genetic component. A list of genetic susceptibility loci in populations of European and Asian ancestry has been established in the literature. Little is known on the inter-ethnic contribution of such established functional polymorphic variants. We performed a case-control study to explore the genetic susceptibility of 16 selected T2DM-related SNPs in a cohort of 102 Uyghur objects (51 cases and 51 controls). Three of the 16 SNPs showed significant association with T2DM in the Uyghur population. There were significant differences between the T2DM and control groups in frequencies of the risk allelic distributions of rs7754840 (CDKAL1) (p=0.014), rs864745 (JAZF1) (p=0.032), and rs35767 (IGF1) (p=0.044). Carriers of rs7754840-C, rs35767-A, and rs864745-C risk alleles had a 2.32-fold [OR (95% CI): 1.19-4.54], 2.06-fold [OR (95% CI): 1.02-4.17], 0.48-fold [OR (95% CI): 0.24-0.94] increased risk for T2DM, respectively. The cumulative risk allelic scores of these 16 SNPs differed significantly between the T2DM patients and the controls [17.1±8.1 vs. 15.4±7.3; OR (95%CI): 1.27(1.07-1.50), p=0.007]. This is the first study to ev...Continue Reading

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Citations

Jun 15, 2016·International Journal of Environmental Research and Public Health·Ping RaoWei Wang
Jan 31, 2013·Journal of the American Academy of Dermatology·April W ArmstrongEhrin J Armstrong
Dec 29, 2017·The Pharmacogenomics Journal·Núria Saigi-MorguiUNKNOWN Swiss Transplant Cohort Study
Nov 17, 2016·Omics : a Journal of Integrative Biology·Camila Pereira BragaPedro de Magalhães Padilha
Mar 7, 2019·Diabetes/metabolism Research and Reviews·Zhe-Zhen LiaoXin-Hua Xiao
Jul 12, 2017·Omics : a Journal of Integrative Biology·Qing GaoManshu Song
Jan 16, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chuanyin LiYiping Li

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