The vaccinia virus B9R protein is a 6 kDa intracellular protein that is non-essential for virus replication and virulence

The Journal of General Virology
Nicola PriceGeoffrey L Smith

Abstract

Vaccinia virus (VV) strain Western Reserve gene B9R is shown to encode an intracellular 6 kDa protein that is expressed late during the infectious cycle. In vitro transcription and translation produced two polypeptides in the presence of microsomal membranes, but only the larger protein in the absence of membranes. The smaller protein sedimented with microsomes during centrifugation, suggesting it was inserted into the lipid membrane or into the microsomal lumen via the N-terminal hydrophobic signal sequence that was subsequently cleaved proteolytically. A VV mutant lacking B9R was constructed and found to replicate normally in cell culture and two in vivo models.

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Citations

Jul 19, 2002·The Journal of General Virology·David C TscharkeGeoffrey L Smith
Sep 28, 2005·The Journal of General Virology·Anna M LikosInger K Damon
Aug 31, 2006·Journal of Virology·E R TulmanD L Rock
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valerie PasquettoAlessandro Sette

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