The vacuolar shapes of ageing: From function to morphology

Biochimica Et Biophysica Acta. Molecular Cell Research
Andreas Aufschnaiter, Sabrina Büttner

Abstract

Cellular ageing results in accumulating damage to various macromolecules and the progressive decline of organelle function. Yeast vacuoles as well as their counterpart in higher eukaryotes, the lysosomes, emerge as central organelles in lifespan determination. These acidic organelles integrate enzymatic breakdown and recycling of cellular waste with nutrient sensing, storage, signalling and mobilization. Establishing physical contact with virtually all other organelles, vacuoles serve as hubs of cellular homeostasis. Studies in Saccharomyces cerevisiae contributed substantially to our understanding of the ageing process per se and the multifaceted roles of vacuoles/lysosomes in the maintenance of cellular fitness with progressing age. Here, we discuss the multiple roles of the vacuole during ageing, ranging from vacuolar dynamics and acidification as determinants of lifespan to the function of this organelle as waste bin, recycling facility, nutrient reservoir and integrator of nutrient signalling.

Citations

Jun 19, 2019·The Journal of Biological Chemistry·Angelina S GrossTobias Eisenberg
Sep 20, 2019·Nature Reviews. Microbiology·Roy Z Moger-Reischer, Jay T Lennon
May 14, 2020·Cells·Verena KohlerSabrina Büttner
Apr 15, 2020·Infection and Immunity·Yoon-Dong ParkPeter R Williamson
Apr 23, 2020·Microorganisms·Alina Grigor'evaElena Ryabchikova
Nov 23, 2020·The Plant Journal : for Cell and Molecular Biology·Germán RobertKohki Yoshimoto
Feb 3, 2020·Mechanisms of Ageing and Development·Vanessa HenkelHeinz D Osiewacz
Dec 9, 2020·International Journal of Medical Microbiology : IJMM·Liping PengMingchun Li
Dec 23, 2020·Yeast·Siyu Sun, David Gresham
Dec 14, 2021·FEBS Letters·Mikael B L WinklerBjørn Panyella Pedersen

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