The vagus afferent network: emerging role in translational connectomics

Neurosurgical Focus
Laureen D HachemGeorge M Ibrahim

Abstract

Vagus nerve stimulation (VNS) is increasingly considered for the treatment of intractable epilepsy and holds potential for the management of a variety of neuropsychiatric conditions. The emergence of the field of connectomics and the introduction of large-scale modeling of neural networks has helped elucidate the underlying neurobiology of VNS, which may be variably expressed in patient populations and related to responsiveness to stimulation. In this report, the authors outline current data on the underlying neural circuitry believed to be implicated in VNS responsiveness in what the authors term the "vagus afferent network." The emerging role of biomarkers to predict treatment effect is further discussed and important avenues for future work are highlighted.

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Citations

Aug 9, 2019·Annals of Neurology·Karim MithaniGeorge M Ibrahim
Aug 31, 2020·Epilepsia·Adriana M WorkewychGeorge M Ibrahim
Nov 1, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Laureen D HachemGeorge M Ibrahim
Jun 13, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Vincent C YeGeorge M Ibrahim
May 16, 2019·Journal of Korean Neurosurgical Society·Ji Hoon Phi, Byung-Kyu Cho
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Mar 26, 2021·Seizure : the Journal of the British Epilepsy Association·Diana Marcela Mejía-GranadosPasquale Striano
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Nov 28, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Brandon SanthumayorShaun Rodgers

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Methods Mentioned

BETA
imaging techniques

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