The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition

Neuroscience
Cecil M Y ChauRuth E Grunau

Abstract

Early stress in the form of repetitive neonatal pain, in infants born very preterm, is associated with long-term dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and with poorer cognitive performance. Brain-derived neurotrophic factor (BDNF) which is important in synaptic plasticity and cognitive functions is reduced by stress. Therefore the BDNF Val66Met variant, which affects secretion of BDNF, may interact with early exposure to pain-related stress in children born very preterm, to differentially affect HPA regulation that in turn may be associated with altered cognitive performance. The aims of this study were to investigate whether in children born very preterm, the BDNF Val66Met variant modulates the association between neonatal pain-related stress and cortisol levels at age 7years, and if cortisol levels were related to cognitive function. Furthermore, we examined whether these relationships were sex-specific. Using a longitudinal cohort design, N=90 children born very preterm (24-32weeks gestation) were followed from birth to age 7years. Cortisol was assayed from hair as an index of cumulative stress and from saliva to measure reactivity to a cognitive challenge. BDNF Val66Met variant was genotyped at 7yea...Continue Reading

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Citations

Sep 28, 2016·Neuroscience·Susanne Brummelte
Mar 2, 2017·Developmental Psychobiology·Amy L D'AgataErin E Young
Jan 19, 2019·Biological Research for Nursing·Sharon G CasavantAngela Starkweather
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Apr 4, 2019·Frontiers in Behavioral Neuroscience·Cecil M Y ChauRuth E Grunau
Jan 5, 2020·Molecular Psychiatry·Michael Notaras, Maarten van den Buuse

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