The validity of different methods of analysis of 133Xe washout curves for the determination of lung function

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
M Rezvani, J W Hopewell

Abstract

The influence of different mathematical methods on the analysis of 133Xe washout data, used in the assessment of lung function in the pig, were investigated. When the data were fitted using a bi-exponential or a bi-exponential plus a constant type equation, neither the two clearance rate constants nor the overall 50% clearance time were found totally appropriate for the study of lung function. A new two compartmental model for the in vivo clearance of 133Xe is proposed. The model assumes the whole blood as one compartment and the lung, including the pulmonary blood, as the second compartment. This suggests that the curvature of the xenon clearance curve is the result of recording the summation of the activities from the alveoli and the pulmonary blood and not, as previously described, due to the existence of two different sub-populations of alveoli.

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Citations

Feb 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M RezvaniJ W Hopewell
Jan 1, 1990·The British Journal of Radiology·M Rezvani, J W Hopewell

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